{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:43:45Z","timestamp":1784861025631,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009158","name":"Kawasaki Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009158","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To clarify the prognosis and prognostic factors for lung cancer in patients with rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective longitudinal study, we investigated the medical records of patients with RA among 1422 patients diagnosed with lung cancer and registered in a hospital\u2010based cancer registry between January 2013 and May 2022. The Kaplan\u2013Meier method and Cox proportional hazards model were used to analyze survival and identify predictive factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 26 patients with RA complicated with lung cancer (median age, 69\u2009years), the 2\u2010year overall survival rates for stages I\u2013II were 90%\u2013100%, and those for stages III\u2013IV were 20%, respectively. Positivity of anti\u2010citrullinated protein\/peptide antibody, smoking history, interstitial lung disease, poorly controlled RA, stage III and IV lung cancer, histological types other than adenocarcinoma and squamous cell carcinoma, and RF\u2009\u2267\u200950\u2009IU\/mL were associated with increased mortality. After the surgical resection of stage I and II lung cancer, 5 of the 16 patients experienced cancer recurrence after resumption of RA treatment, and the histology of the recurrent cancers was mostly squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early detection of lung cancer is needed, especially in patients with RA who have a history of smoking, seropositivity, or interstitial lung disease. Even after surgical resection, it should be noted that squamous cell carcinoma is prone to recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.15069","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T04:45:01Z","timestamp":1711082701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prognosis and prognostic factors of lung cancer complications in patients with rheumatoid arthritis"],"prefix":"10.1111","volume":"27","author":[{"given":"Shunichi","family":"Fujita","sequence":"first","affiliation":[{"name":"Department of Rheumatology Kawasaki Medical School  Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1272-2997","authenticated-orcid":false,"given":"Kazuhisa","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Kawasaki Medical School  Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Nagasu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Kawasaki Medical School  Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumie","family":"Hiramatsu\u2010Asano","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Kawasaki Medical School  Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Akagi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Kawasaki Medical School  Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Kawasaki Medical School  Kurashiki Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10705"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009741003604542"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0728-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002465"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4382-x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/mr\/roac085"},{"key":"e_1_2_11_8_1","unstructured":"Cancer Statistics.Cancer Information Service National Cancer Center Japan (National Cancer Registry Ministry of Health Labour and Welfare).https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9633299\/"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyq167"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.je.2016.12.010"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181d2dcd9"},{"key":"e_1_2_11_12_1","unstructured":"MatsuiT.Research on the actual medical treatment and problems in patients with rheumatoid arthritis (in Japanese). A shared research report for 2018. Ministry of Health Labor and Welfare Scientific Research Grant for Systemic Autoimmune Diseases2019. 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