{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T21:23:24Z","timestamp":1774992204715,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T00:00:00Z","timestamp":1708819200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001744"],"award-info":[{"award-number":["82001744"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH265"],"award-info":[{"award-number":["ZR2021MH265"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aims to evaluate the long\u2010term efficacy, safety, and cumulative retention rate of antitumor necrosis factor\u2010alpha (anti\u2010TNF\u2010\u03b1) therapy for patients with Behcet's uveitis (BU) using meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the Web of Science and PubMed databases for eligible studies up to December 1, 2022. The quality of each identified study was assessed using the Joanna Briggs Institute's case series literature quality assessment tool. Statistical analysis was conducted using Stata 16.0 software with a random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve studies comprising 1156 patients with BU were included in our analysis. We found that 85.0% of patients achieved ocular inflammation remission after receiving anti\u2010TNF\u2010\u03b1 treatment, with a 95% confidence interval (CI) ranging from 78.7% to 90.5%. Additionally, 77.4% (95% CI: 57.5%\u201392.5%) experienced an improvement in visual acuity (VA). Moreover, the pooled dose reduction of glucocorticoids (GCs) was 11.08\u2009mg (95% CI: \u221213.34\u2009mg to \u22128.83\u2009mg). Throughout the follow\u2010up period, the cumulative retention rate of the medication was 67.3% (95% CI: 53.7%\u201379.6%). Serious adverse events occurred in 5.8% (95% CI: 3.1%\u20138.9%) of cases, with the three most common types being severe infusion or injection reactions (2.7%; 95% CI: 0.8%\u20135.4%), tuberculosis (1.3%; 95% CI: 0.0%\u20133.9%), and bacterial pneumonia (1.3%; 95% CI: 0.1%\u20133.4%). Subgroup analysis revealed that ocular inflammation remission rates were 89.3% (95% CI: 81.2%\u201395.5%) for adalimumab treatment and 83.7% (95% CI: 75.3%\u201390.8%) for infliximab treatment. The drug retention rate after adalimumab therapy was 70.3% (95% CI: 62.0%\u201378.0%) compared to 66.4% (95% CI: 48.6%\u201382.2%) for infliximab treatment. Furthermore, the incidence of severe infusion or injection reactions was 2.2% (95% CI: 0.1%\u20135.8%) following adalimumab treatment and 3.5% (95% CI: 0.7%\u20137.7%) following infliximab treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anti\u2010TNF\u2010\u03b1 therapy represents an effective treatment for BU patients with favorable safety profile and high drug retention rate and a potential advantage of adalimumab over infliximab in terms of ocular inflammation remission, drug retention, and the incidence of severe infusion or injection reactions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.15096","type":"journal-article","created":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T08:10:20Z","timestamp":1708848620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010term efficacy, safety, and cumulative retention rate of antitumor necrosis factor\u2010alpha 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