{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:28:21Z","timestamp":1788672501495,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to analyze the muscle magnetic resonance imaging (MRI) findings of patients with antineutrophilic cytoplasmic antibody\u2010associated vasculitis (AAV) and polyarteritis nodosa (PAN) presenting with clinical symptoms in the extremities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis was conducted on short tau inversion recovery MRI findings, with a focus on intramuscular vessels displaying abnormal perivascular signals, in 22 and eight patients with AAV and PAN, respectively. The number per unit area (4\u2009cm<jats:sup>2<\/jats:sup>) and diameter of abnormal vessels on muscle MRI were compared between patients with AAV and those with PAN. Cut\u2010off values, clinical sensitivity, and specificity for these indices were calculated from the receiver operating characteristic curves to distinguish between AAV and PAN, and the relationship between the indices and clinical findings in AAV was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of abnormal vessels per unit area was significantly higher in AAV compared to PAN (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Additionally, the diameter of the abnormal vessels was significantly higher in PAN than in AAV (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The presence of &gt;6.44 abnormal vessels per unit area or \u22643.61\u2009mm diameter of abnormal vessels was able to predict AAV (sensitivity, 0.955; specificity, 0.625). AAV patients with peripheral neuropathy exhibited a significantly higher number of abnormal vessels per unit area than those without peripheral neuropathy (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Muscle MRI can detect small\u2010 to medium\u2010vessel vasculitis and be a valuable tool for distinguishing between patients with AAV and PAN experiencing clinical symptoms in the extremities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.15116","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T03:26:40Z","timestamp":1711164400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of characteristics of muscle magnetic resonance imaging findings in patients with antineutrophilic cytoplasmic antibody\u2010associated vasculitis and polyarteritis nodosa"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0754-8051","authenticated-orcid":false,"given":"Haruyasu","family":"Ito","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Radiology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9245-0513","authenticated-orcid":false,"given":"Kentaro","family":"Noda","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Ukichi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daitaro","family":"Kurosaka","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002507"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2020.101589"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6154"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-015-0747-1"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.1.117"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1530-3"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-021-01407-y"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42045"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.7110"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/eqd0ch"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.14774"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-815677"},{"issue":"5","key":"e_1_2_14_14_1","first-page":"945","article-title":"Muscle involvement in polyarteritis nodosa: report of a patient presenting clinically as polymyositis and review of the literature","volume":"21","author":"Fort JG","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-232854"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-020-04652-y"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-017-3841-z"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2017.17067"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e318262e3dd"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/pn-2022-003536"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:3<421::AID-ANR5>3.0.CO;2-6"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2019.12.002"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37715"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.054593"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330805"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2017.06.011"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-021-00315-7"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.101279"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq400"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.15116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T09:43:42Z","timestamp":1711446222000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.15116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/1756-185X.15116"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.15116","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15116"}}