{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:59:14Z","timestamp":1762102754231,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100020830","name":"AYUMI Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020830","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010740","name":"Asahi Kasei Pharma Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010740","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Hounsfield units (HU) measured using computed tomography (CT) have gained considerable attention for the detection of osteoporosis. This study aimed to investigate whether opportunistic CT could predict vertebral fractures in patients with rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 233 patients with RA who underwent chest CT were included in this study. The HU values of the anterior 1\/3 of the vertebral bodies based on the sagittal plane at T11\u2013L2 after reconstruction were measured. The incidence of vertebral fractures was investigated with respect to the HU value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vertebral fractures were identified in 32 patients during a mean follow\u2010up period of 3.8\u2009years. In patients who experienced vertebral fractures within 2\u2009years of CT imaging, the HU values of the vertebral bodies (T11\u2013L2) were lower than those in patients who did not experience fractures. Receiver operating characteristic curve analysis identified that a T11 HU value of &lt;125 was a risk factor for vertebral fracture within 2\u2009years. Multivariate analysis showed that a T11 HU value of &lt;125 and the existence of prevalent vertebral fractures were significant risk factors for fracture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HU measurements of the anterior 1\/3 of the vertebral body are a potential predictor for vertebral fractures in patients with RA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.15146","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T12:44:04Z","timestamp":1714049044000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low Hounsfield unit values on computed tomography as a potential predictor of vertebral fracture in patients with rheumatoid arthritis: The <scp>KURAMA<\/scp> cohort study"],"prefix":"10.1111","volume":"27","author":[{"given":"Akane","family":"Umeda","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Kyoto 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