{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:38:17Z","timestamp":1759401497784,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008717","name":"Sylvia and Charles Viertel Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009809","name":"John T. Reid Charitable Trusts","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the direct health service costs and resource utilization associated with diagnosing and characterizing idiopathic inflammatory myopathies (IIMs), and to assess for limitations and diagnostic delay in current practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective, single\u2010center cohort analysis of all patients diagnosed with IIMs between January 2012 and December 2021 in a large tertiary public hospital was conducted. Demographics, resource utilization and costs associated with diagnosing IIM and characterizing disease manifestations were identified using the hospital's electronic medical record and Health Intelligence Unit, and the Medicare Benefits Schedule.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010eight IIM patients were identified. IIM subtypes included dermatomyositis (34.2%), inclusion body myositis (18.4%), immune\u2010mediated necrotizing myopathy (18.4%), polymyositis (15.8%), and anti\u2010synthetase syndrome (13.2%). The median time from symptom onset to diagnosis was 212\u2009days (IQR: 118\u2013722), while the median time from hospital presentation to diagnosis was 30\u2009days (8\u2013120). Seventy\u2010six percent of patients required emergent hospitalization during their diagnosis, with a median length of stay of 8\u2009days (4\u201315).<\/jats:p><jats:p>The average total cost of diagnosing IIM was $15\u2009618 AUD (STD: 11331) per patient. Fifty percent of patients underwent both MRI and EMG to identify affected muscles, 10% underwent both pan\u2010CT and PET\u2010CT for malignancy detection, and 5% underwent both open surgical and percutaneous muscle biopsies. Autoimmune serology was unnecessarily repeated in 37% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The diagnosis of IIMs requires substantial and costly resource use; however, our study has identified potential limitations in current practice and highlighted the need for streamlined diagnostic algorithms to improve patient outcomes and reduce healthcare\u2010related economic burden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.15153","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T12:33:44Z","timestamp":1714048424000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnosing and characterizing inflammatory myopathies at an Australian tertiary public hospital: Resource utilization and direct healthcare costs"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1555-1177","authenticated-orcid":false,"given":"Victoria","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Rheumatology The Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Ciciriello","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandana","family":"Nikpour","sequence":"additional","affiliation":[{"name":"The University of Melbourne at St Vincent's Hospital  Fitzroy Victoria Australia"},{"name":"The University of Sydney  Camperdown New South Wales Australia"},{"name":"Royal Prince Alfred Hospital Sydney  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shereen","family":"Oon","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"The University of Melbourne at St Vincent's Hospital  Fitzroy Victoria Australia"},{"name":"The Walter and Eliza Hall Institute of Medical Research  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8528-4361","authenticated-orcid":false,"given":"Jessica","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"The Walter and Eliza Hall Institute of Medical Research  Parkville Victoria Australia"},{"name":"Department of Medical Biology The University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"1094","article-title":"Incidence of inflammatory myopathies in Victoria, Australia, and evidence of spatial clustering","volume":"26","author":"Patrick M","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2011.01669.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-015-0120-1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2016.1151433"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2018.1486294"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2021.07.016"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25686"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101083"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23190"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2006.11.005"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211468"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-023-01045-w"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_11_15_1","unstructured":"Australian Government Department of Health and Aged Care.Medicare benefits schedule online. 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