{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:35:49Z","timestamp":1787168149382,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Many rheumatoid arthritis (RA) patients prioritize pain improvement in treatment. As pain can result from various causes, including noninflammatory factors such as central sensitivity syndrome (CSS), we hypothesized that CSS might impact treatment satisfaction. In this cross\u2010sectional study, we assessed the CSS effects on clinical disease activity and treatment satisfaction in RA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 220 consecutive RA patients receiving long\u2010term follow\u2010up were evaluated for clinical disease activity and treatment satisfaction. CSS was evaluated using the Central Sensitization Inventory (CSI). An overall score of \u226540 indicates the presence of CSS. We queried \u201cHow satisfied are you with your treatment?\u201d; answers included (a) very satisfied, (b) satisfied, (c) not satisfied, or (d) very dissatisfied. For univariate analysis, we condensed these answers into \u201cdissatisfied\u201d or \u201csatisfied.\u201d We also evaluated treatment satisfaction using the visual analog scale (VAS), with scores ranging from 0\u2009mm (very dissatisfied) to 100\u2009mm (very satisfied).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 220 patients, 17 (7.7%) were classified as having CSS. CSI score was significantly correlated with the clinical disease activity index (CDAI;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009.322,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01) and treatment satisfaction (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2212.336,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01). Regarding treatment satisfaction, univariate analysis revealed that patient global assessment (PtGA), pain VAS, Health Assessment Questionnaire\u2010Disability Index (HAQ\u2010DI), Disease Activity Score in 28 joints with C\u2010reactive protein, CDAI, and CSI scores of patients who were satisfied with treatment differed significantly from those of dissatisfied patients. Multivariate analysis revealed that CSI, PtGA, and HAQ\u2010DI scores were associated with treatment satisfaction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In RA patients, CSS may affect the disease activity index and reduce treatment satisfaction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.15159","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:08:30Z","timestamp":1714090110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Central sensitivity syndrome affects the disease activity index and treatment satisfaction in patients with rheumatoid arthritis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0440-0848","authenticated-orcid":false,"given":"Kazushige","family":"Seki","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Yamaguchi University Graduate School of Medicine  Ube Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Imagama","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Yamaguchi University Graduate School of Medicine  Ube Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Yamaguchi University Graduate School of Medicine  Ube Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Yamaguchi University Graduate School of Medicine  Ube Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Yamaguchi University Graduate School of Medicine  Ube Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001290"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-019-0156-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S24752"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.022699"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0525-5"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201491"},{"issue":"5","key":"e_1_2_10_9_1","first-page":"S14","article-title":"The health assessment questionnaire (HAQ)","volume":"23","author":"Bruce B","year":"2005","journal-title":"Clin Exp 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M","year":"1997","journal-title":"Am J Manag Care"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez506"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12311"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000027"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S289692"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-019-00168-5"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.15159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T08:36:33Z","timestamp":1714120593000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.15159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/1756-185X.15159"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.15159","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2024-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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