{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T11:53:23Z","timestamp":1782129203704,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies have reported low serum 25\u2010hydroxyvitamin D [25(OH)D] levels in dermatomyositis (DM) patients, but the exact causal relationship between them remains elusive. Our aim is to confirm the causal relationship between 25(OH)D and DM risk through a Mendelian randomization study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrieve genome\u2010wide association study (GWAS) data on 25(OH)D (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009441\u2009291) and DM (\n                      <jats:italic>n<\/jats:italic>\n                      cases\u2009=\u2009201,\n                      <jats:italic>n<\/jats:italic>\n                      controls\u2009=\u2009172\u2009834) from the GWAS database (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/gwas.mrcieu.ac.uk\/\">https:\/\/gwas.mrcieu.ac.uk\/<\/jats:ext-link>\n                      ). Select single\u2010nucleotide polymorphisms (SNPs) strongly correlated with 25(OH)D as instrumental variables (IVs). The primary analytical approach involves the use of the inverse\u2010variance weighted method (IVW), supplemented by MR\u2010Egger regression and weighted median methods to enhance the reliability of the results. Heterogeneity and sensitivity analyses were conducted using Cochran's Q and leave\u2010one\u2010out approaches, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The IVW analysis confirmed a positive causal relationship between genetic variation in 25(OH)D levels and DM (OR\u2009=\u20092.36, 95% CI\u2009=\u20091.01\u20135.52,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.048). Although not statistically significant (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.05), the other methods also suggested a protective effect of 25(OH)D on DM. Based on MR\u2010Egger intercepts and Cochran's Q analysis, the selected SNPs showed no horizontal pleiotropy and heterogeneity. Sensitivity analysis demonstrated the robustness of the results against individual SNPs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We provide the first evidence of a causal relationship between 25(OH)D levels and DM. Our findings support the importance of measuring serum 25(OH)D levels and considering vitamin D supplementation in clinical practice for patients with DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.15204","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:51:45Z","timestamp":1717462305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum 25\u2010hydroxyvitamin D levels and dermatomyositis: A 2\u2010sample mendelian randomization study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0025-8100","authenticated-orcid":false,"given":"Wei","family":"Feng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Traditional Chinese Medicine Syndrome, The First Clinical Medical College of Guangzhou University of Chinese Medicine  Guangzhou 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