{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T01:24:49Z","timestamp":1787448289905,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The relevance of tubulo\u2010interstitial involvement for kidney prognosis has recently been emphasized, but validated biomarkers for predicting histology are still lacking. The aim of our study was to evaluate different serum and urinary markers of tubular damage in patients with lupus nephritis (LN) and to correlate them with kidney histopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010center retrospective study was conducted from January 2016 to December 2021. Serum and urine samples were collected on the same day of kidney biopsy and correlated with histologic data from a cohort of 15 LN patients. We analyzed the following urinary markers, adjusted for urine creatinine: beta 2\u2010microglobulin, alpha 1\u2010microglobulin, NGAL, uKIM\u20101, MCP\u20101, uDKK\u20103, and uUMOD. The serum markers sKIM\u20101 and sUMOD were also analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A positive and strong correlation was observed between the degree of interstitial fibrosis (rho\u2009=\u20090.785,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001) and tubular atrophy (rho\u2009=\u20090.781,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001) and the levels of uDKK3. uUMOD also showed an inverse and moderate correlation with interstitial fibrosis (rho\u2009=\u2009\u22120.562,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.037) and tubular atrophy (rho\u2009=\u2009\u22120.694,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.006). Patients with &gt;10% cortical interstitial inflammation had higher levels of uKIM\u20101 [4.9 (3.9, 5.5) vs. 0.8 (0.6, 1.5) mcg\/mg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001], MCP\u20101 [3.8 (2. 3, 4.2) vs. 0.7 (0.3, 1.2) mcg\/mg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001], sKIM\u20101 [9.2 (5.9, 32.7) vs. 1.4 (0, 3.5) pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001], and lower sUMOD [8.7 (0, 39.7) vs. 46.1 (35.7, 53) ng\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.028].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of specific urinary and serum biomarkers of tubular dysfunction or injury may help to predict certain histologic parameters in LN patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.15210","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T04:26:12Z","timestamp":1717475172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tubular biomarkers and histology in lupus nephritis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0946-6619","authenticated-orcid":false,"given":"Javier","family":"Carbayo","sequence":"first","affiliation":[{"name":"Department of Nephrology Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00darsula","family":"Verdalles","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid 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Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Blanco","sequence":"additional","affiliation":[{"name":"Renal Pathophysiology Laboratory Instituto Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Cristobal","family":"Redondo","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Garc\u00eda\u2010G\u00e1miz","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Goicoechea","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital General Universitario 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