{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:40:42Z","timestamp":1787697642892,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,6]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n To determine whether the IG count (#) and IG percentage (%) are associated with disease activity in rheumatoid arthritis (RA).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective study included 65 RA patients and 65 healthy controls. Clinical and demographic characteristics of controls and RA patients (at active period and when the patients achieved remission) were obtained from medical records. Disease activity was defined by disease activity score 28 (DAS28). Furthermore, the clinical disease activity index (CDAI), and simple disease activity index (SDAI) were calculated. For the differential diagnosis of RA patients from healthy controls, the cut\u2010off value was estimated by making receiver\u2010operator curves (ROC).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In active RA patients, erythrocyte sedimentation rate (ESR), C\u2010reactive protein (CRP), IG#, and IG% levels were significantly higher compared to the healthy controls (\n p<\/jats:italic>\n \u2009<\u2009.001, for all). When the patients achieved remission, DAS28, CDAI, SDAI, ESR, CRP, IG#, and IG% values were significantly decreased (\n p<\/jats:italic>\n \u2009<\u2009.001, for all). IG# and IG% were significantly positively correlated with DAS28, CDAI, SDAI, ESR, and CRP (\n p<\/jats:italic>\n \u2009=\u2009.024,\n p<\/jats:italic>\n \u2009=\u2009.008,\n p<\/jats:italic>\n \u2009=\u2009.003,\n p<\/jats:italic>\n \u2009<\u2009.001,\n p<\/jats:italic>\n \u2009<\u2009.001, respectively). According to ROC curve analysis, IG% and IG# were the biomarkers to have a significant diagnostic value for RA with the area under the curve of 0.853 and 0.865 (\n p<\/jats:italic>\n \u2009<\u2009.001, for all).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The present study demonstrated that two novel inflammatory markers, IG# and IG%, can be useful for monitoring RA patients' disease activity. Furthermore, IG# and IG% can also be used as fast, inexpensive, and easily available complementary diagnostic markers to diagnose RA patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1756-185x.15216","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T04:53:36Z","timestamp":1718340816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Relationship of immature granulocytes with disease activity in rheumatoid arthritis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1915-2330","authenticated-orcid":false,"given":"Nurten","family":"Seringec\u00a0Akkececi","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Kahramanmaras Sutcu Imam University Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8017-6502","authenticated-orcid":false,"given":"Muhammed","family":"Ciftcioglu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Kahramanmaras Sutcu Imam University Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9028-9930","authenticated-orcid":false,"given":"Burak","family":"Okyar","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine Kahramanmaras Sutcu Imam University Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9680-7535","authenticated-orcid":false,"given":"Gozde","family":"Yildirim\u00a0Cetin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine Kahramanmaras Sutcu Imam University Kahramanmaras 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granulocytes predict severe acute pancreatitis independently of systemic inflammatory response syndrome","volume":"12","author":"Lipi\u0144ski M","year":"2017","journal-title":"Prz 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effective and reliable marker in grad\u0131ng the severity of acute cholecystitis: increased immature granulocyte percentage","volume":"28","author":"\u00dcnal Y","year":"2022","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"e_1_2_12_28_1","first-page":"56","article-title":"A new inflammation marker in rheumatoid arthritis: immature granulocyte","volume":"25","author":"\u00d6zcan E","year":"2023","journal-title":"K\u00dc T\u0131p Fak Derg"}],"container-title":["International Journal of Rheumatic 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