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For decades, IFN\u2010I has been hypothesized to be essential in the development of systemic lupus erythematosus (SLE), a chronic multisystem autoimmunity characterized by immune complex (IC) deposition in small vessels. Recent findings revealed that the activation of the cGAS\u2013STING pathway by self\u2010DNA would propagate the autoimmune responses via upregulating IFN\u2010I production in SLE. In this review, we aimed to provide a comprehensive outlook of the role of the cGAS\u2013STING pathway in SLE pathobiology, as well as, a better understanding of current therapeutic opportunities targeting this axis.<\/jats:p>","DOI":"10.1111\/1756-185x.15256","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T03:19:52Z","timestamp":1720581592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Harnessing\n                    <scp>cGAS<\/scp>\n                    \u2013\n                    <scp>STING<\/scp>\n                    axis for therapeutic benefits in systemic lupus erythematosus"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4888-6541","authenticated-orcid":false,"given":"Liu","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Henan Provincial Hospital of Traditional Chinese Medicine Henan 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