{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:26:01Z","timestamp":1784035561237,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2017YFC0907601"],"award-info":[{"award-number":["2017YFC0907601"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2017YFC0907605"],"award-info":[{"award-number":["2017YFC0907605"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to evaluate the long\u2010term survival, causes of death, and prognostic factors in Chinese patients with primary Sj\u00f6gren syndrome (pSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included patients with pSS registered in the Chinese Rheumatism Data Centre between May 2016 and December 2021, and collected baseline clinical, laboratory, and treatment data. Survival and standard mortality rates were calculated using general population mortality data. Factors related to mortality were identified using Cox proportional hazards regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 8588 patients included, 274 died during a median follow\u2010up of 4.0\u2009years. The overall standardized mortality ratio was 1.61 (95% CI: 1.43\u20131.81). Overall survival rates were 98.2% at 5\u2009years and 93.8% at 10\u2009years. The predominant causes of death were comorbidities, including cardiovascular diseases, tumors, and infections, while the most frequent pSS\u2010related causes of death were interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH). Male sex, older age, ILD, PAH, and high EULAR Sj\u00f6gren's syndrome\u00a0disease activity index (ESSDAI), thrombocytopenia, anemia, high immunoglobulin A (IgA) level, and glucocorticoid treatment independently increased the mortality risk, while using hydroxychloroquine was a protective factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mortality rates have significantly increased in Chinese patients with pSS. Comorbidities, rather than pSS\u2010related organ damage, were the main causes of death. All\u2010cause mortality was associated with male sex, older age, ILD, PAH, high ESSDAI, thrombocytopenia, anemia, high IgA level, and glucocorticoid treatment, whereas hydroxychloroquine use might improve the long\u2010term survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.15284","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T01:03:39Z","timestamp":1726448619000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Long\u2010term survival analysis of patients with primary Sj\u00f6gren's syndrome in China: A multicenter retrospective cohort study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9018-6237","authenticated-orcid":false,"given":"Li","family":"Yueting","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital  Beijing China"},{"name":"Chinese Academy of Medical Sciences Peking Union Medical College  Beijing China"},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC\u2010DID), Ministry of Science &amp; 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