{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:25:09Z","timestamp":1753878309423,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009049","name":"Tunghai University","doi-asserted-by":"publisher","award":["TCVGH\u2010T1127803"],"award-info":[{"award-number":["TCVGH\u2010T1127803"]}],"id":[{"id":"10.13039\/100009049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH\u2010NCHU1110124","TCVGH\u2010YM1090103","TCVGH\u2010VHCY1108607","TCVGH\u20101119101D","TCVGH\u20101129101D","TCVGH\u2010YM1110109"],"award-info":[{"award-number":["TCVGH\u2010NCHU1110124","TCVGH\u2010YM1090103","TCVGH\u2010VHCY1108607","TCVGH\u20101119101D","TCVGH\u20101129101D","TCVGH\u2010YM1110109"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the psoriatic disease risk among patients with previous appendicitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a nationwide population\u2010based case\u2013control study about the association between the psoriatic disease risk among patients with a history of appendicitis in Taiwan. The study population consisted of newly diagnosed psoriatic disease with at least two outpatient visits, and the control group included those patients without psoriatic disease at the same index date. Patients with a previous diagnosis of appendicitis or who underwent appendectomy surgery prior to their psoriatic disease diagnosis were recorded. The odds ratio of psoriatic disease diagnosis in the two groups with and without a history of appendicitis were analyzed and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 48\u2009894 individuals diagnosed with psoriatic disease were matched with 292\u2009656 controls by age and gender. Notably, the proportion of patients with a history of appendicitis or primary appendectomy was significantly elevated among those with psoriatic disease compared with the control cohort (both <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). On average, the occurrence of appendicitis preceded the index date by 3.3\u2009\u00b1\u20092.3\u2009years. Multivariate analysis revealed a heightened incidence rate of psoriatic disease in patients previously diagnosed with appendicitis, periodontal disease, Charlson comorbidity index score (CCIS) \u22671, and ill\u2010defined intestinal infections. This association persisted after adjusting for confounding factors, such as periodontal disease, CCIS, <jats:italic>Salmonella<\/jats:italic>, and ill\u2010defined intestinal infections. The odds ratios for psoriatic disease in individuals with a history of appendicitis, periodontal disease, CCIS \u22671, and ill\u2010defined intestinal infections were 1.16, 1.008, 1.69, and 1.23, respectively, with corresponding 95% confidence intervals of 1.03\u20131.31, 1.05\u20131.11, 1.65\u20131.74, and 1.20\u20131.26. These findings underscore the independent association between appendicitis and subsequent development of psoriatic disease, even after adjusting for relevant comorbidities and potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our research illustrates that appendicitis is associated with an increased likelihood of developing a psoriatic disease, despite several limitations. These limitations encompass variables such as dietary and smoking habits, alongside other potential confounding factors that were not fully considered. Moreover, inherent biases in utilizing national health insurance data, such as the absence of laboratory information, as well as the constraints inherent in a retrospective study design, should be acknowledged.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.15289","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T16:29:58Z","timestamp":1726676998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Appendicitis links to the afterward subsequent psoriatic disease occurrence in Taiwan national health insurance research database: A population\u2010based cohort study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1207-646X","authenticated-orcid":false,"given":"Chung\u2010Yuan","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology, Kaohsiung Chang Gung Memorial Hospital and School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7274-3458","authenticated-orcid":false,"given":"Yu\u2010Jih","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology, Kaohsiung Chang Gung Memorial Hospital and School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan, ROC"},{"name":"College of Medicine National Sun Yat\u2010sen University  Kaohsiung Taiwan, ROC"},{"name":"Institute of Biopharmaceutical Sciences National Sun Yat\u2010sen University  Kaohsiung Taiwan, ROC"},{"name":"Institute of Medical Science and Technology National Sun Yat\u2010sen University  Kaohsiung Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung\u2010Heng","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Cishan Hospital, Ministry of Health and Welfare  Kaohsiung Taiwan, ROC"},{"name":"Department of Senior Services Industry Management Minghsin University of Science and Technology  Hsinchu Taiwan, ROC"},{"name":"Department of Recreation and Sport Management Shu\u2010Te University  Kaohsiung Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsian\u2010Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Research Taichung Veterans General Hospital  Taichung Taiwan, ROC"},{"name":"Center for Quantitative Imaging in Medicine, Department of Medical Research Taichung Veterans General Hospital  Taichung City Taiwan, ROC"},{"name":"Department of Computer Science and Information Engineering National United University  Miaoli City Taiwan, ROC"},{"name":"Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine Chung Hsing University  Taichung Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Cheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Surgery Chi Mei Medical Center  Tainan Taiwan, ROC"},{"name":"Department of Information Management National Chung Cheng University  Chiayi Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-4587","authenticated-orcid":false,"given":"Hsin\u2010Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of General Medicine and Division of Allergy, Immunology and Rheumatology Taichung Veterans General Hospital  Taichung Taiwan, ROC"},{"name":"Institute of Biomedical Science, Rong Hsing Research Centre for Translational Medicine and Big Data Center Chung Hsing University  Taichung Taiwan, ROC"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan, ROC"},{"name":"Department of Industrial Engineering and Enterprise Information Tunghai University  Taichung Taiwan, ROC"},{"name":"Institute of Public Health and Community Medicine Research Center National Yang\u2010Ming University  Taipei Taiwan, 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