{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:17:15Z","timestamp":1787170635779,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001745","name":"Asia Pacific League of Associations for Rheumatology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001745","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,9]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n To investigate the correlation between T\u2010cell senescence with the atherosclerosis markers in patients with systemic lupus erythematosus (SLE).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The study participants were 40 female SLE patients aged 18\u201345\u2009years who met the 2019 EULAR\/ACR criteria and 40 healthy individuals. The atherosclerosis markers were investigated using the Doppler ultrasonography examinations to measure the cIMT (carotid intima\u2010media thickness) and flow\u2010mediated dilation (FMD) and serological markers using soluble ICAM\u20101 and VCAM\u20101. Flow cytometry of CD4\n +<\/jats:sup>\n CD57\n +<\/jats:sup>\n , CD8\n +<\/jats:sup>\n CD57\n +<\/jats:sup>\n , CD4\n +<\/jats:sup>\n CD28\n null<\/jats:sup>\n , and CD8\n +<\/jats:sup>\n CD28\n null<\/jats:sup>\n T cells were used to assess the immunosenescence markers.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The cIMT (\n p<\/jats:italic>\n \u2009<\u2009.001), sICAM\u20101 (\n p<\/jats:italic>\n \u2009<\u2009.001), and sVCAM\u20101 (\n p<\/jats:italic>\n \u2009<\u2009.001) were significantly higher in SLE patients compared with control, while FMD was significantly lower in SLE patients (\n p<\/jats:italic>\n \u2009<\u2009.001). The percentages of all T\u2010cell senescence markers are also significantly higher in SLE patients than in healthy individuals. Positive correlations were shown between cIMT with the CD4\n +<\/jats:sup>\n CD57\n +<\/jats:sup>\n (\n R<\/jats:italic>\n \u2009=\u2009.301,\n p<\/jats:italic>\n \u2009=\u2009.005), CD4\n +<\/jats:sup>\n CD28\n null<\/jats:sup>\n (\n R<\/jats:italic>\n \u2009=\u2009.448,\n p<\/jats:italic>\n \u2009<\u2009.001), and CD8\n +<\/jats:sup>\n CD28\n null<\/jats:sup>\n (\n R<\/jats:italic>\n \u2009=\u2009.422,\n p<\/jats:italic>\n \u2009<\u2009.001). Conversely, negative correlations were demonstrated between the FMD with CD4\n +<\/jats:sup>\n CD57\n +<\/jats:sup>\n (\n R<\/jats:italic>\n \u2009=\u2009\u2212.236,\n p<\/jats:italic>\n \u2009=\u2009.023), CD8\n +<\/jats:sup>\n CD57\n +<\/jats:sup>\n (\n R<\/jats:italic>\n \u2009=\u2009\u2212.409,\n p<\/jats:italic>\n \u2009<\u2009.001), CD4\n +<\/jats:sup>\n CD28\n null<\/jats:sup>\n (\n R<\/jats:italic>\n \u2009=\u2009\u2212.422,\n p<\/jats:italic>\n \u2009<\u2009.001), and CD8\n +<\/jats:sup>\n CD28\n null<\/jats:sup>\n (\n R<\/jats:italic>\n \u2009=\u2009\u2212.318,\n p<\/jats:italic>\n \u2009=\u2009.003). The soluble markers of sICAM\u20101 and sVCAM\u20101 were also positively correlated with the T\u2010cell senescence markers.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Early sign of atherosclerosis was demonstrated in patients with SLE in this study. T\u2010cell senescence markers had significant correlations with the atherosclerosis markers, including the cIMT, FMD, and soluble adhesion molecules levels. Understanding the link between immunosenescence and atherosclerosis might help to identify a new method for early detection and treatment of atherosclerosis in SLE.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1756-185x.15339","type":"journal-article","created":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T21:14:17Z","timestamp":1726434857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["T\u2010cell senescence was correlated with early atherosclerosis in\u00a0patients with systemic lupus erythematosus"],"prefix":"10.1111","volume":"27","author":[{"given":"Mirza Zaka","family":"Pratama","sequence":"first","affiliation":[{"name":"Rheumatology Division, Department of Internal Medicine, Faculty of Medicine Universitas Brawijaya, Saiful Anwar General Hospital Malang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesarius Singgih","family":"Wahono","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Department of Internal Medicine, Faculty of Medicine Universitas Brawijaya, Saiful Anwar General Hospital Malang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Bayhaqi Nasir","family":"Aslam","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Universitas Brawijaya, Saiful Anwar General Hospital Malang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syahrul","family":"Chilmi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine Universitas Brawijaya, Saiful Anwar General Hospital Malang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidia Purnama","family":"Sari","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Department of Internal Medicine, Faculty of Medicine Universitas Brawijaya, Saiful Anwar General Hospital Malang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anugrah","family":"Abdurrohman","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Department of Internal Medicine, Faculty of Medicine Universitas Brawijaya, Saiful Anwar General Hospital Malang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ike","family":"Sulistiyowati","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Universitas Brawijaya, Saiful Anwar General Hospital Malang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Aditya","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Universitas Brawijaya, Saiful Anwar General Hospital Malang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxie Felix","family":"Johono","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine Universitas Brawijaya, Saiful Anwar General Hospital Malang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Robert","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine Universitas Brawijaya, Saiful Anwar General Hospital Malang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00772"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2478\/rir-2021-0022"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20322"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2631"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20163878"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32835ada13"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2021.110318"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13816"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/09612033211038057"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90431-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(95)80017-M"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI95146"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2021.04.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.22027"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203305lu2200oa"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-08-1102"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-021-01455-6"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.10.003"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9940-z"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002270"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2019.1624769"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.21931\/RB\/CSS\/2023.08.02.61"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2022.115664"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.109365.1"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009122"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.763930"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz919"},{"issue":"2","key":"e_1_2_8_29_1","first-page":"84","article-title":"The role of immunosenescence in the development of age\u2010related diseases","volume":"68","author":"F\u00fcl\u00f6p T","year":"2016","journal-title":"Rev Investig Clin"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2017.07.002"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.246"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2021.102615"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023184"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-014-1473-1"},{"issue":"8","key":"e_1_2_8_35_1","article-title":"Glucocorticoid\u2010induced cardiomyopathy caused by uncontrollable asthma","volume":"15","author":"Uehara H","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8097539"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00177"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.15339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T09:56:24Z","timestamp":1727344584000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.15339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/1756-185X.15339"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.15339","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15339"}}