{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T06:03:34Z","timestamp":1774073014888,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Ergostatrien\u20103\u03b2\u2010ol (EK100) is a bioactive compound found in the fruiting bodies and mycelia of <jats:italic>Antrodia cinnamomea<\/jats:italic> and has anti\u2010inflammatory and immunomodulatory properties. This study aims to evaluate the potential of EK100 as a treatment for Sj\u00f6gren's syndrome (SS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We employed a spontaneous SS model in non\u2010obese diabetic (NOD)\/Ltj mice to assess the therapeutic potential of EK100. The effects of EK100 were evaluated based on stimulated salivary flow rates, sialadenitis, expression of inflammatory cytokines in salivary glands, and profiles of T cell subsets in the spleen. Additionally, in\u00a0vitro experiments were conducted to assess the impact of EK100 on Th17 cell differentiation and dendritic cell (DC) maturation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>EK100 treatment significantly increased salivary flow rates, suppressed lymphocyte infiltration, and decreased the concentrations of anti\u2010SSA\/Ro and anti\u2010SSB\/La autoantibodies. EK100 also downregulated the expression of various inflammatory cytokines in the salivary glands and reduced the populations of Th1 and Th17 cells in the spleens of NOD\/Ltj mice. In\u00a0vitro experiments confirmed that EK100 inhibited the differentiation of Th17 cells and the maturation of DCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that EK100 may offer a promising therapeutic avenue for the treatment of SS by modulating the interaction between Th17 cells and DCs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.15341","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T12:25:38Z","timestamp":1730809538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the potential of Ergostatrien\u20103\u03b2\u2010ol for treating Sj\u00f6gren's syndrome"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8109-6996","authenticated-orcid":false,"given":"Po\u2010Chang","family":"Wu","sequence":"first","affiliation":[{"name":"Doctoral Program in Translational Medicine 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