{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T03:56:40Z","timestamp":1774756600771,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21DZ2201200"],"award-info":[{"award-number":["21DZ2201200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871276"],"award-info":[{"award-number":["81871276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Beh\u00e7et's syndrome (BS) is a variant vessel vasculitis that can involve multiple organs, with highly heterogeneous clinical manifestations. This study aims to analyze baseline data of BS patients to enhance the comprehension of its clinical features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 1216 registered cases of BS patients referred to Huadong Hospital affiliated with Fudan University. Each patient was thoroughly assessed and recorded for demographic data, clinical manifestations, gastrointestinal endoscope, imaging, etc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant gender differences were observed in clinical manifestations. Pseudofolliculitis (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), uveitis (<jats:italic>p<\/jats:italic>\u2009=\u2009.003), vascular (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and cardiovascular involvement (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) were significantly more prevalent in male BS patients, while genital ulcers (<jats:italic>p<\/jats:italic>\u2009=\u2009.011) and erythema nodosum (<jats:italic>p<\/jats:italic>\u2009=\u2009.009) were more common among the female. Furthermore, pseudofolliculitis (44.3%, 37.4% vs. 25.0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), pathergy test positivity (37.0%, 24.5% vs. 12.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and uveitis (18.8%, 18.4% vs. 11.2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) showed higher incidence rates in the 16\u201335\u2009years age group. Vascular involvement (11.1%, 18.0% vs. 15.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) notably increased in the 36\u201350\u2009years age group. Additionally, the ISG diagnostic criteria were more likely to be met in the 16\u201335 age group (OR: 2.039, 95% CI: 1.581\u20132.631, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), whereas the ICBD criteria were less likely to be met in the 16\u201335 age group (OR: 0.266, 95% CI: 0.150\u20130.474, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provided data on the baseline of clinical features of BS in a single center, BS patients presented significant heterogeneity, showing different manifestations across various genders and age groups. This diversity might contribute to a better understanding of BS clinical features and pave the way for future multi\u2010center studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.15355","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T09:45:22Z","timestamp":1728294322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical characteristics of Beh\u00e7et's syndrome in Shanghai database: Baseline data of a cross\u2010sectional cohort study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-8011","authenticated-orcid":false,"given":"Chun\u2010Hui","family":"She","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Huadong Hospital Affiliated to Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010fei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Huadong Hospital Affiliated to Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Huadong Hospital Affiliated to Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua\u2010Fang","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Huadong Hospital Affiliated to Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6481-480X","authenticated-orcid":false,"given":"Jian\u2010Long","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Huadong Hospital Affiliated to Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.1098351"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2021.1834853"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-011-0120-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez626"},{"issue":"6","key":"e_1_2_11_6_1","first-page":"808","article-title":"2018 update of the EULAR recommendations for the management of Beh\u00e7et's syndrome","volume":"77","author":"Hatemi G","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-019-02046-y"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.08.013"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-019-02154-9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.713052"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00718-8"},{"issue":"8697","key":"e_1_2_11_12_1","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease. International study Group for Beh\u00e7et's disease","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12107"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-92616-8_12"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-022-02937-0"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-018-0715-8"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.639758"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05536-z"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02830"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.208"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000125"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000520696"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04570-w"},{"issue":"6","key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/RHU.0000000000001996","article-title":"Characteristics of patients with Beh\u00e7et disease from the Van Province, eastern Turkey: definition of disease clusters in a tertiary referral center","volume":"29","author":"Oguz E","year":"2023","journal-title":"J Clin Rheumatol"},{"issue":"6","key":"e_1_2_11_25_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/RHU.0000000000001987","article-title":"Clinical characteristics and outcomes of Mexican patients with Beh\u00e7et's syndrome","volume":"29","author":"Hinojosa\u2010Azaola A","year":"2023","journal-title":"J Clin Rheumatol"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12265"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7371458"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7209-3"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken162"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-018-0843-5"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.117436"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-012-0307-x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-020-00301-y"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00301-1"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70015-8"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10215174"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1536\/jhj.43.389"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-020-02406-6"},{"issue":"5","key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/02648725.2023.2208452","article-title":"Mapping themes, trends, and knowledge structure of Behcet syndrome: a bibliometric analysis from 2010 to 2021","volume":"5","author":"Wu H","year":"2023","journal-title":"Biotechnol Genet Eng Rev"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu233"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.15355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T12:50:17Z","timestamp":1729860617000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.15355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/1756-185X.15355"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.15355","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2023-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15355"}}