{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:35:49Z","timestamp":1785796549486,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The effects of biologic and targeted synthetic disease\u2010modifying anti\u2010rheumatic drugs (b\/tsDMARDs) and conventional synthetic disease\u2010modifying anti\u2010rheumatic drugs (csDMARDs) on body composition and muscle function in rheumatoid arthritis (RA) patients requiring treatment enhancement were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter, prospective, observational study (PRESENT Study) divided RA patients non\u2010randomly into a csDMARD group (<jats:italic>n<\/jats:italic>\u2009=\u2009100) and a b\/tsDMARD group (<jats:italic>n<\/jats:italic>\u2009=\u2009100). Changes in body composition and muscle function were examined in 80 patients in each group followed for 52\u2009weeks. The percentages of new\u2010onset and improved sarcopenia over 1 year were investigated. Patients in the b\/tsDMARD group were divided into three groups by drug type: TNF inhibitors (<jats:italic>n<\/jats:italic>\u2009=\u200930), non\u2010TNF inhibitors (<jats:italic>n<\/jats:italic>\u2009=\u200923), and JAK inhibitors (<jats:italic>n<\/jats:italic>\u2009=\u200927).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline median age and disease duration were 70.0 and 4.0\u2009years, respectively. Changes in weight (24 and 52\u2009weeks) and muscle mass (52\u2009weeks) were significantly higher in the b\/tsDMARD group (<jats:italic>p<\/jats:italic>\u2009=\u2009.035, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, and <jats:italic>p<\/jats:italic>\u2009=\u2009.002, respectively). On multivariate logistic regression analysis, b\/tsDMARD treatment (OR 3.21, <jats:italic>p<\/jats:italic>\u2009=\u2009.002), DAS28\u2010ESR (OR 0.65 <jats:italic>p<\/jats:italic>\u2009=\u2009.011), and muscle mass (OR 0.90, <jats:italic>p<\/jats:italic>\u2009=\u2009.023) were independently associated with increased muscle mass at 52\u2009weeks. The percentages of new\u2010onset and improved sarcopenia were almost equal. There were no significant differences in the time\u2010dependent changes (52\u2009weeks) of clinical status, body composition, muscle function, and status of sarcopenia among TNF inhibitors, non\u2010TNF inhibitors, and JAK inhibitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Weight and muscle mass increased significantly more with b\/tsDMARD than with csDMARD treatment. There were no differences in body composition changes by mode of action with b\/tsDMARDs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.15371","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T08:34:42Z","timestamp":1728462882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Biologic and targeted synthetic disease\u2010modifying anti\u2010rheumatic drugs improve body composition in rheumatoid arthritis patients more than conventional synthetic disease\u2010modifying anti\u2010rheumatic drugs: Results from the <scp>PRESENT<\/scp> study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-3929","authenticated-orcid":false,"given":"Masahiro","family":"Tada","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Osaka City General Hospital  Osaka 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Anno","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Yodogawa Christian Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Koryokai Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of General Medical Osaka City General Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Osaka City General Hospital  Osaka 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