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While the precise cause of RA is uncertain, various research has been conducted to gain a better understanding of the immunological processes involved in the development of RA. T cells are acknowledged as significant contributors to the progression of RA because of their roles in cytokine secretion, antigen presentation, and facilitating B cells in the manufacture of antibodies. \u03b3\u03b4 T cells are a small subset of T cells that have significant functions in the context of infection and diseases linked with tumors. \u03b3\u03b4 T cells have been the subject of investigation in autoimmune disorders in recent years. This review focused on the involvement of \u03b3\u03b4 T lymphocytes in the development of RA. In this article, we provide an analysis of the immunological capabilities of \u03b3\u03b4 T cells, intending to comprehend their significance in RA, which could be pivotal in the creation of innovative clinical treatments.<\/jats:p>","DOI":"10.1111\/1756-185x.15381","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T18:22:15Z","timestamp":1730139735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The recent progress of \u03b3\u03b4 T cells and its targeted therapies in rheumatoid arthritis"],"prefix":"10.1111","volume":"27","author":[{"given":"Xue","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Bone and Joint Surgery The First Bethune Hospital of Jilin University  Changchun 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