{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:22:20Z","timestamp":1789042940194,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Parvovirus B19 infection has been associated with various clinical entities including musculoskeletal manifestations and the development of different autoimmune diseases. The aim of our study is to examine the musculoskeletal manifestations associated with acute parvovirus B19 infection and the possible development of chronic autoimmune rheumatic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Retrospective cohort study that included adult hospitalized patients diagnosed with an acute parvovirus B19 infection between 1 January 2021 and 1 February 2024. Subjects were followed\u2010up for 6\u201312\u2009months after hospitalization aiming to identify patients who developed chronic autoimmune rheumatic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 23 patients diagnosed with acute parvovirus B19 infection. Patients were predominantly females (16, 69.6%) with mean age at diagnosis of 39.3\u2009\u00b1\u200913.11\u2009years. Most patients were Jewish (15, 65.2%). The two most common acute symptoms were fever (82.6%) and myalgia (56.5%). Polyarthritis was present only in three patients (13%) and all of them had wrists involvement. Anti\u2010nuclear antibodies and rheumatoid factor were the most common autoantibodies present with equal prevalence each (13%). Five patients were treated with prednisone during the acute phase (21%), two (8.7%) of them needed drug escalation and were subsequently treated with hydroxychloroquine and methotrexate. One patient developed systemic lupus erythematosus during the first 6\u2009months of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Musculoskeletal manifestations developing during acute parvovirus B19 are usually self\u2010limited with only a small minority of patients developing chronic autoimmune diseases. It is crucial to differentiate self\u2010limited manifestations related to acute parvovirus B19 from idiopathic autoimmune diseases aiming to avoid unnecessary immunosuppressive therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.15409","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T05:28:48Z","timestamp":1731130128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Rheumatic manifestations and sequela of acute parvovirus <scp>B19<\/scp> infection in hospitalized adult population"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9648-1130","authenticated-orcid":false,"given":"Fadi","family":"Hassan","sequence":"first","affiliation":[{"name":"Rheumatology Unit Galilee Medical Center  Naharyia Israel"},{"name":"The Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasim","family":"Khoury","sequence":"additional","affiliation":[{"name":"The Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"},{"name":"Internal Medicine \u201cE\u201d Galilee Medical Center  Naharyia Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rula","family":"Daood","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Galilee Medical Center  Naharyia Israel"},{"name":"The Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Saab","sequence":"additional","affiliation":[{"name":"The Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"},{"name":"Internal Medicine \u201cE\u201d Galilee Medical Center  Naharyia Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9777-2864","authenticated-orcid":false,"given":"Mohammad E.","family":"Naffaa","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Galilee Medical Center  Naharyia Israel"},{"name":"The Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8624-6332","authenticated-orcid":false,"given":"Helana","family":"Jeries","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Galilee Medical Center  Naharyia Israel"},{"name":"The Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"491","article-title":"The international committee on taxonomy of viruses","volume":"133","author":"Virus taxonomy update","year":"1993","journal-title":"Arch Virol"},{"key":"e_1_2_10_3_1","first-page":"4","article-title":"Parvovirus infection of the human fetus and newborn","volume":"9","author":"Berry PJ","year":"1992","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91126-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890230409"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/157.4.663"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.7.2326-2329.1999"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37997454023.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02407.x"},{"key":"e_1_2_10_10_1","first-page":"152","article-title":"Aplastic anemia due to B19 parvovirus infection in cadaveric renal transplant recipients: an underestimated infectious disease in the immunocompromised host","volume":"10","author":"Bertoni E","year":"1997","journal-title":"J Nephrol"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200101150-00010"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000357650"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)92152-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830390209"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91145-6"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90235-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91146-8"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2002.00789.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)09110-6"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91445-X"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92802-8"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1989.00390050111022"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.7.597"},{"key":"e_1_2_10_24_1","first-page":"576","article-title":"Human parvovirus B19 infection is not followed by inflammatory joint disease during long term follow\u2010up. A retrospective study of 54 patients","volume":"16","author":"Speyer I","year":"1998","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.05485-0"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2015-203455"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2007.09.013"},{"key":"e_1_2_10_28_1","first-page":"373","article-title":"Clinical presentations of parvovirus B19 infection","volume":"75","author":"Servey JT","year":"2007","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00040-16"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2005.09.002"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.07.005"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00561-1"},{"key":"e_1_2_10_33_1","first-page":"342","article-title":"Detection of parvovirus B19 capsid proteins in lymphocytic cells in synovial tissue of autoimmune chronic arthritis","volume":"59","author":"Mehraein Y","year":"2003","journal-title":"Mod Pathol"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.19498"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2004.07.008"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(95)80001-8"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-004-0494-5"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.12890\/2020_001729"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.15409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T10:34:10Z","timestamp":1735814050000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.15409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/1756-185X.15409"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.15409","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15409"}}