{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:53:04Z","timestamp":1775091184465,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate objective cut\u2010off values for Bath ankylosing Spondylitis Disease Activity Index (BASDAI) corresponding to Ankylosing Spondylitis Disease Activity Score with CRP (ASDAS) cut\u2010off values (1.3, 2.1, and 3.5), and for interval changes (\u0394BASDAI) corresponding to \u0394ASDAS (1.1 and 2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this multicentric study, adult patients with active axial spondyloarthritis (axSpA) treated with either tofacitinib 5\u2009mg twice daily or adalimumab 40\u2009mg subcutaneously fortnightly were recruited. Available paired data on BASDAI and ASDAS and paired interval change of these parameters (taken at least 3\u2010months apart) were analyzed. Cut\u2010off values for BASDAI were determined from a multinomial logistic regression and that for \u0394BASDAI were determined with ordinal logistic regression with predicted probabilities. Diagnostics were assessed with correct classification rate (CRR), polychoric correlations (PCC), Goodman and Kruskal Gamma (GKG), and Matthew's correlation coefficient (MCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total 962 observations of paired data and 670 interval change data were available from 266 patient (mean age 35\u2009years, mean disease duration 7\u2009years, mean BASDAI 2.7, and mean ASDAS 2.1). Following ASDAS classes were observed: inactive disease 131 (13.6%), moderate disease activity 322 (33.5%), high disease activity 420 (43.65%), and very high disease activity 89 (9.25%). The three cut\u2010offs generated for BASDAI were 0.8, 2.5, and 6 for BASDAI and those for \u0394BASDAI were 2 and 4. The CRR for BASDAI cut\u2010offs was 65.59 and that for \u0394BASDAI was 54.9. For the BASDAI cut\u2010offs, both PCC and GKG showed high values (&gt;\u20090.85) and the MCC was 0.471.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with axSpA, without any clinical or serological confounders, BASDAI values 0.8, 2.5, and 6 corresponded to ASDAS\u2010CRP values 1.3, 2.1, and 3.5, respectively, and \u0394BASDAI values of 2 and 4 correspond to \u0394ASDAS cut\u2010offs of 1.1 and 2.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.15418","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T11:36:03Z","timestamp":1731929763000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Defining Objective <scp>BASDAI<\/scp> Cut\u2010Offs for Disease Activity States and Improvement Scores in Axial Spondyloarthritis: A Multicentric Collaboration"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8670-1745","authenticated-orcid":false,"given":"Rudra Prosad","family":"Goswami","sequence":"first","affiliation":[{"name":"Department of Rheumatology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1497-0388","authenticated-orcid":false,"given":"Moumita","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Statistics Aliah University  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7307-5749","authenticated-orcid":false,"given":"Shyamashis","family":"Das","sequence":"additional","affiliation":[{"name":"Consultant Rheumatologist Institute of Neurosciences\u2010Kolkata  Kolkata 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