{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T03:01:16Z","timestamp":1771210876904,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Type 2 lepromatous reaction is a severe complication triggered by proinflammatory cytokines, it affects patients with lepromatous leprosy and border lepromatous leprosy. This reaction can occur before, during, or after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>We report a case of acute polyarthritis as type 2 lepromatous reaction debut. A 30\u2010year\u2010old male with a history of Hansen's disease 5\u2009years ago received a complete therapeutic regimen with cure criteria. Consulted due to a 3\u2010day history of arthralgia predominantly affecting the hands, knees, and feet. On the fifth day of hospitalization, the patient developed intensely painful, nodular erythematous lesions. The pathological history, clinical presentation, and the presence of polymorphonuclear cells led to the diagnosis of type 2 lepromatous reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Identifying individuals with risk factors or a history of leprosy, along with a high index of suspicion, positively impacts the early identification of leprosy reactions as an imitator of other causes of acute or chronic symmetrical polyarthritis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.15437","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:08:22Z","timestamp":1733270902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Acute Additive Polyarthritis as a Presentation of Type 2 Lepromatous Reaction: The Role of Differential Diagnosis"],"prefix":"10.1111","volume":"27","author":[{"given":"Gloria Caterine","family":"P\u00e9rez Mingan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Universidad de Cartagena  Cartagena Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruny Carolina","family":"Llamas Castellanos","sequence":"additional","affiliation":[{"name":"Department of Dermatology Universidad de Cartagena  Cartagena Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esa\u00fa del Cristo","family":"\u00c1lvarez Lora","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Universidad de Cartagena  Cartagena Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Judith","family":"Palomino Vergara","sequence":"additional","affiliation":[{"name":"Universidad de Cartagena Medical School  Cartagena Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Camacho Chaljub","sequence":"additional","affiliation":[{"name":"Department of Dermatology Universidad de Cartagena  Cartagena Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"e_1_2_1_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004065"},{"key":"e_1_2_1_9_3_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2006.74.868"},{"issue":"10","key":"e_1_2_1_9_4_1","article-title":"Recognizing and Managing the Immunologic Reactions in Leprosy","volume":"7","author":"Voorend C. G. N.","year":"2013","journal-title":"Journal of the American Academy of Dermatology"},{"key":"e_1_2_1_9_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_561_19"},{"key":"e_1_2_1_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.034"},{"issue":"3","key":"e_1_2_1_9_7_1","first-page":"911","article-title":"Detection of Transforming Growth Factor\u2010Beta 1 in Dermal Lesions of Different Clinical Forms of Leprosy","volume":"148","author":"Goulart I. M.","year":"1996","journal-title":"American Journal of Pathology"},{"key":"e_1_2_1_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq264"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.15437","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.15437","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.15437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T02:05:39Z","timestamp":1771207539000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.15437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":7,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/1756-185X.15437"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.15437","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15437"}}