{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:39:46Z","timestamp":1791848386329,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to determine whether the concurrent presence of tubulointerstitial inflammation (TII) and tubulointerstitial damage (TID) predicts the progression of chronic kidney disease (CKD) in patients with lupus nephritis (LN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from 175 LN patients, collected at the time of renal biopsy, were analyzed. Patients were stratified into two groups based on the presence or absence of coexisting TII\/TID. Uni\u2010 and multivariable Cox proportional hazard regression models were utilized to identify independent risk factors for CKD in LN patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 175 patients, 110 (62.9%) exhibited coexisting TII\/TID, whereas 65 (37.1%) did not. Patients with coexisting TII\/TID tended to be older and presented with higher levels of ESR and 24\u2010h proteinuria, as well as lower levels of eGFR and hemoglobin compared to those without coexisting TII\/TID. Over a mean follow\u2010up period of 89.9\u2009months, CKD and end\u2010stage renal disease occurred more frequently in patients with coexisting TII\/TID. Notably, the presence of coexisting TII\/TID was associated with a higher risk of CKD progression, with adjusted hazard ratios of 2.667 (95% CI: 1.333, 5.335,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) for all LN patients, 3.265 (95% CI: 1.451, 7.345,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) for those with class III, IV, and V LN, and 3.045 (95% CI: 1.289, 7.195,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) for those with class III, IV, V LN, and eGFR \u2265\u200930\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LN patients with coexisting TII\/TID are at a heightened risk of kidney function deterioration at LN onset and subsequent development of CKD over the long term.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.15444","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T08:34:33Z","timestamp":1733474073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Coexisting Tubulointerstitial Inflammation and Damage Is a Risk Factor for Chronic Kidney Disease in Patients With Lupus Nephritis"],"prefix":"10.1111","volume":"27","author":[{"given":"Hyemin","family":"Jeong","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Chonnam National University Medical School and Hospital  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Eun","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Chonnam National University Medical School and Hospital  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1113-2001","authenticated-orcid":false,"given":"Ji\u2010Hyoun","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Chonnam National University Medical School and Hospital  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Shin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Chonnam National University Medical School &amp; Hospital  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo\u2010Duk","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology Chonnam National University Medical School &amp; Hospital  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Chonnam National University Medical School and Hospital  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6810-7355","authenticated-orcid":false,"given":"Shin\u2010Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Chonnam National University Medical School and Hospital  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12212"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39594"},{"issue":"5","key":"e_1_2_10_4_1","first-page":"709","article-title":"The Risk of Cardiovascular Morbidity and Cardiovascular Mortality in Systemic Lupus Erythematosus and Lupus Nephritis: A Danish Nationwide Population\u2010Based Cohort Study","volume":"56","author":"Hermansen M. 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