{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:44:38Z","timestamp":1788572678007,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies against nuclear antigens and immune complex deposition. The pathogenesis of SLE is not fully understood; however, there are alterations in neutrophils and lymphocytes. Recent parameters assessing both neutrophil activations (Neut\u2010RI, Neut\u2010GI, IG) and activated lymphocytes (Re\u2010Lymp, As\u2010Lymp) can be used to assess the activation of immune cells. The aim of this study was to explore the potential role of this parameter in detecting active SLE.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Cross\u2010sectional study using secondary data from Hasan Sadikin Lupus Registry. Parameters were examined using Sysmex XN\u20101500. Lupus activity was determined according to SLEDAI\u20102K.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n This study included 30 active (SLEDAI 2K\u2009\u2265\u20094) and 30 inactive SLE patients. Compared to inactive SLE, active SLE showed significantly higher Neut\u2010RI (51.5 vs. 49.6 FL,\n p<\/jats:italic>\n \u2009=\u20090.004), and lower Re\u2010Lymph (0.09 vs. 0.14\u2009\u00d7\u200910\n 3<\/jats:sup>\n \/mm\n 3<\/jats:sup>\n ,\n p<\/jats:italic>\n \u2009=\u20090.024). There was no significant difference in Neut\u2010GI (150 vs. 151.6 SI,\n p<\/jats:italic>\n \u2009=\u20090.359), As\u2010Lymp (0.02 vs. 0.01\u2009\u00d7\u200910\n 3<\/jats:sup>\n \/mm\n 3<\/jats:sup>\n ,\n p<\/jats:italic>\n \u2009=\u20090.621), and IG (0.11 vs. 0.06\u2009\u00d7\u200910\n 3<\/jats:sup>\n \/mm\n 3<\/jats:sup>\n ,\n p<\/jats:italic>\n \u2009=\u20090.384) between active and inactive SLE. Neut\u2010RI\/Re\u2010Lymp ratio cutoff >\u20090.47 could distinguish between active and inactive SLE with AUC 0.689, 66.7% sensitivity, and 70.0% specificity.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In active SLE, there is an elevation in Neut\u2010RI and a reduction in Re\u2010Lymp. Neut\u2010RI\/Re\u2010Lymp ratio exceeding 0.47 could be used to detect active SLE.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1756-185x.15449","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T05:06:13Z","timestamp":1733807173000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Potential Role of Neutrophil Reactivity Intensity and Reactive Lymphocytes as Extended Hematological Parameters to Detect Active Systemic Lupus Erythematosus"],"prefix":"10.1111","volume":"27","author":[{"given":"Andri Iskandar","family":"Mardia","sequence":"first","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran\/Dr. Hasan Sadikin General Hospital Bandung Indonesia"},{"name":"Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Sumatera Utara Medan Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1310-674X","authenticated-orcid":false,"given":"Laniyati","family":"Hamijoyo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran\/Dr. Hasan Sadikin General Hospital Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Susandi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran\/Dr. Hasan Sadikin General Hospital Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delita","family":"Prihatni","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine Universitas Padjadjaran\/Dr. Hasan Sadikin General Hospital Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bachti","family":"Alisjahbana","sequence":"additional","affiliation":[{"name":"Division of Tropical Medicine, Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran\/Dr. Hasan Sadikin General Hospital Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7853-2221","authenticated-orcid":false,"given":"Amaylia","family":"Oehadian","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran\/Dr. Hasan Sadikin General Hospital Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1100359"},{"issue":"10","key":"e_1_2_10_3_1","article-title":"An Overview of Systemic Lupus Erythematosus (SLE) Pathogenesis, Classification, and Management","volume":"14","author":"Ameer M. A.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_10_4_1","first-page":"684","article-title":"What's Wrong With Neutrophils in Lupus?","volume":"37","author":"Tsai C. 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D.","year":"2002","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9216528"},{"key":"e_1_2_10_18_1","article-title":"The Usefulness of Extended Inflammation Parameters and Systemic Inflammatory Response Markers in the Diagnostics of Autoimmune Hepatitis","volume":"11","author":"Domerecka W.","year":"2022","journal-title":"Cell Journal"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress\u20102020.2447"},{"issue":"2","key":"e_1_2_10_20_1","first-page":"1","article-title":"Novel Haematological Parameters for Rapidly Monitoring the Immune System Response","volume":"27","author":"Sysmex Europe GmbH","year":"2017","journal-title":"Sysmex Journal International"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203320950822"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1033"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.67.1.40"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.15449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.15449","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.15449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T02:05:12Z","timestamp":1771207512000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.15449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/1756-185X.15449"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.15449","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15449"}}