{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:06:58Z","timestamp":1781129218590,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>In this study, we aimed to evaluate and compare the characteristics of pediatric and adult rhupus patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty pediatric patients with rhupus syndrome and 15 adult patients with rhupus syndrome were included in this study. Similarities and differences between both groups were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The time elapsed between the diagnosis of juvenile idiopathic arthritis (JIA)\/rheumatoid arthritis (RA) and the diagnosis of systemic lupus erythematosus (SLE) was longer in adults than in pediatric patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). While the most common phenotypes at disease onset were JIA\/RA in both adults and children, SLE was more prevalent in pediatric patients and RA in adult patients at the last visit (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Cutaneous findings, oral ulcers, hematological and renal involvement, hypocomplementemia, and antidouble\u2010stranded DNA positivity were more frequent in pediatric patients, whereas constitutional findings, nonscarring alopecia, neuropsychiatric involvement, and anticyclic citrullinated peptide positivity were more common in adults (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Asymmetric polyarthritis was more prevalent in pediatric patients, whereas symmetric polyarthritis was more common in adult patients (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Erosive arthritis was more frequently observed in adult patients (p\u2009&lt;\u20090.001). In the treatment, mycophenolate mofetil was more commonly prescribed to pediatric patients, while rituximab was more frequently used for adult patients in the treatment of SLE compared to pediatric patients (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Additionally, leflunomide was more commonly used in JIA\/RA treatment in adult patients compared to pediatric patients (p\u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first study comparing pediatric and adult patients with rhupus syndrome. Revealing these differences and similarities will contribute significantly to the literature.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70082","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T06:13:49Z","timestamp":1737440029000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Differences and Similarities Between Children and Adults With Rhupus Syndrome"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1564-8996","authenticated-orcid":false,"given":"Seher","family":"Sener","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Division of Pediatric Rheumatology, Department of Pediatrics Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilara","family":"Unal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Pediatric Rheumatology, Department of Pediatrics Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezgi Deniz","family":"Batu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Pediatric Rheumatology, Department of Pediatrics Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gozde Sevgi","family":"Kart Bayram","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Rheumatology, Department of Internal Medicine Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Busra","family":"Firlatan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Rheumatology, Department of Internal Medicine Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levent","family":"Kilic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Rheumatology, Department of Internal Medicine Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sezgin","family":"Sahin","sequence":"additional","affiliation":[{"name":"Cerrahpasa Faculty of Medicine, Department of Pediatrics, Department of Pediatric Rheumatology Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Gezgin Yildirim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics, Department of Pediatric Rheumatology Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miray","family":"Kisla Ekinci","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics, Department of Pediatric Rheumatology Cukurova University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Kisaoglu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics, Department of Pediatric Rheumatology Karadeniz Technical University  Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Karali","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics, Division of Immunology and Rheumatology Uludag University  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selcan","family":"Demir","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics, Department of Pediatric Rheumatology Eskisehir Osmangazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ummusen","family":"Kaya Akca","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics Aydin Gynecology and Children's Hospital  Ayd\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aybuke","family":"Gunalp","sequence":"additional","affiliation":[{"name":"Cerrahpasa Faculty of Medicine, Department of Pediatrics, Department of Pediatric Rheumatology Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyma","family":"Turkmen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Rheumatology, Health Sciences University Umraniye Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulsah","family":"Kavrul Kayaalp","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics, Department of Pediatric Rheumatology Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceyda","family":"Arslanoglu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Division of Pediatric Rheumatology, Department of Pediatrics Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruya","family":"Torun","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics, Department of Pediatric Rheumatology Dokuz Eylul University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hulya","family":"Ercan Emreol","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Pediatric Rheumatology, Department of Pediatrics Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge","family":"Basaran","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Pediatric Rheumatology, Department of Pediatrics Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysenur","family":"Pac Kisaarslan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Division of Pediatric Rheumatology, Department of Pediatrics Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"Sozeri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Rheumatology, Health Sciences University Umraniye Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuray","family":"Aktay Ayaz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics, Department of Pediatric Rheumatology Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevcan Azime","family":"Bakkaloglu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics, Department of Pediatric Rheumatology Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Sebnem","family":"Kilic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics, Division of Immunology and Rheumatology Uludag University  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukaddes","family":"Kalyoncu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics, Department of Pediatric Rheumatology Karadeniz Technical University  Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelda","family":"Bilginer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Pediatric Rheumatology, Department of Pediatrics Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erbil","family":"Unsal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics, Department of Pediatric Rheumatology Dokuz Eylul University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgur","family":"Kasapcopur","sequence":"additional","affiliation":[{"name":"Cerrahpasa Faculty of Medicine, Department of Pediatrics, Department of Pediatric Rheumatology Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sule","family":"Apras Bilgen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Rheumatology, Department of Internal Medicine Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seza","family":"Ozen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Pediatric Rheumatology, Department of Pediatrics Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"821","volume-title":"Cecil\u2010Loeb Textbook of Medicine","author":"Schur P.","year":"1971"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081067"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/819629"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6194738"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/09612033231226353"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1988.00380070117028"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102612"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203311400113"},{"issue":"4","key":"e_1_2_12_10_1","first-page":"346","article-title":"Childhood Rhupus Syndrome","volume":"52","author":"Mitra S.","year":"2015","journal-title":"Indian Pediatrics"},{"issue":"2","key":"e_1_2_12_11_1","first-page":"390","article-title":"International League of Associations for Rheumatology Classification of Juvenile Idiopathic Arthritis: Second Revision, Edmonton, 2001","volume":"31","author":"Petty R. E.","year":"2004","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30100"},{"key":"e_1_2_12_14_1","first-page":"41","volume-title":"Mixed Connective Tissue Disease and Antinuclear Antibodies","author":"Kasukawa R.","year":"1987"},{"key":"e_1_2_12_15_1","first-page":"33","volume-title":"Mixed Connective Tissue Disease and Antinuclear Antibodies","author":"Alarcon\u2010Segovia D.","year":"1987"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203314526439"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203318793715"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-3127-3"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.09.004"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000049"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2017-000555"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313482741"},{"issue":"135","key":"e_1_2_12_23_1","first-page":"14","article-title":"Safety and Efficacy of Etanercept\u2010Methotrexate Combination Therapy in Patients With Rhupus: An Observational Study of Non\u2010glucocorticoid Treatment","volume":"25","author":"Yang B.\u2010B.","year":"2018","journal-title":"Discovery Medicine"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010022\u201001824\u2010x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59101841"},{"issue":"4","key":"e_1_2_12_26_1","first-page":"563","article-title":"Efficacy and Safety of Pharmacokinetically\u2010Driven Dosing of Mycophenolate Mofetil for the Treatment of Pediatric Proliferative Lupus Nephritis\u2010A Double\u2010Blind Placebo Controlled Clinical Trial (The Pediatric Lupus Nephritis Mycophenolate Mofetil Study)","volume":"14","author":"Sagcal Gironella A. C. P.","year":"2024","journal-title":"Journal of Clinical Trials"},{"issue":"6","key":"e_1_2_12_27_1","first-page":"1182","article-title":"Leflunomide for the Treatment of Rheumatoid Arthritis: A Systematic Review and Metaanalysis","volume":"30","author":"Osiri M.","year":"2003","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315627199"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080091"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.70082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.70082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.70082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:20:38Z","timestamp":1773746438000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.70082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/1756-185X.70082"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.70082","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70082"}}