{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:25Z","timestamp":1787013745340,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T00:00:00Z","timestamp":1738454400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although chronic inflammatory arthropathies (CIA) are associated with sarcopenia, sarcopenia plays a role in their pathogenesis remains unknown. This study investigated the causal relationship between sarcopenia and CIA and to identify potential mediating factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined data from 458\u2009910 participants in the UK Biobank to analyze the association between sarcopenia\u2010related traits and CIA. Associations between hand\u2010grip strength, muscle mass, walking pace, and CIA were analyzed using Cox regression models. Then, we performed a mediation analysis to explore the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Individuals with low hand\u2010grip strength exhibited a 1.88\u2010fold (95% CI 1.73\u20132.05), 2.22\u2010fold (95% CI 2.02\u20132.45), and 1.36\u2010fold (95% CI 1.32\u20131.41) increased risk of rheumatoid arthritis (RA), spondyloarthritis (SpA), and osteoarthritis (OA), respectively. The HRs for sarcopenia were 1.64 (95% CI 1.15\u20132.32) for RA, 1.83 (95% CI 1.21\u20132.77) for SpA, and 1.26 (95% CI 1.09\u20131.45) for OA. Additionally, individuals with a slow walking pace exhibited a 1.83\u2010fold (95% CI 1.66\u20132.02), 3.58\u2010fold (95% CI 3.25\u20133.95), and 1.82\u2010fold (95% CI 1.77\u20131.88) increased risk of RA, SpA, and OA, respectively. Furthermore, we identified inflammatory markers as possible mediators of the causal effects of low hand\u2010grip strength on the development of CIA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that sarcopenia is independently associated with an increased risk of CIA, which is partially mediated by inflammation factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70100","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T02:50:12Z","timestamp":1738551012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Causal Association Between Chronic Inflammatory Arthropathies and Sarcopenia and the Mediation Role of Inflammatory Factors"],"prefix":"10.1111","volume":"28","author":[{"given":"Yanyan","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Haiyan People's Hospital  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics 7th Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Economics and Management China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Rheumatology &amp; Immunology, Shanghai Sixth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Division of Rheumatology and Clinical Immunology, Department of Medicine Queen Mary Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Faculty of Orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine &amp;Rehabilitation  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2027-3650","authenticated-orcid":false,"given":"Shengjie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Capital Medical University School of Rehabilitation Medicine China Rehabilitation Research Center  Beijing 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