{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:57:51Z","timestamp":1770501471480,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["(82170858\uff0c82470935)"],"award-info":[{"award-number":["(82170858\uff0c82470935)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Life's Essential 8 (LE8) is a recently updated algorithm for evaluating cardiovascular health (CVH). This study investigates the association between LE8 and mortality risk among individuals with arthritis in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study using data from the US National Health and Nutritional Examination Survey (NHANES) 2005\u20132018. Participants with arthritis were included. Mortality data, including underlying causes of death, were obtained through linkage to national death records up to December 31, 2019. LE8 components (diet, physical activity, nicotine exposure, sleep, body mass index, blood lipids, glucose, and pressure) were measured and scored from 0 to 100. The total LE8 score, calculated as the unweighted average of all components, was categorized into low (0\u201349), moderate (50\u201379), and high (80\u2013100) CVH. We employed Kaplan\u2013Meier curves to estimate survival probabilities and weighted Cox proportional hazards regression models to evaluate hazard ratios (HRs) with 95% confidence intervals (CIs) for all\u2010cause and cardiovascular disease (CVD) mortality. Stratified analyses and interaction tests were performed to explore potential effect modifications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 4519 participants with arthritis (median follow\u2010up: 7.67\u2009years), we observed 793 all\u2010cause deaths, including 213 CVD deaths. Every 10\u2010point increase in the LE8 score was associated with a 17% lower risk of all\u2010cause mortality (HR: 0.83, 95% CI: 0.77\u20130.89) and a 25% lower risk of CVD mortality (HR: 0.75, 95% CI: 0.66\u20130.85). Compared to the lowest CVH tertile, individuals in the highest tertile demonstrated a 38% lower risk of all\u2010cause mortality (HR: 0.62, 95% CI: 0.41\u20130.92) and a 62% lower risk of CVD mortality (HR: 0.38, 95% CI: 0.18\u20130.80). Kaplan\u2013Meier survival curves revealed significantly higher survival probability for patients with high CVH compared to those with lower CVH (log\u2010rank <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Stratified analyses confirmed consistent associations across various subgroups. Similar findings were observed in sensitivity analyses focusing on osteoarthritis and other arthritis subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher adherence to LE8 recommendations is associated with reduced risks of all\u2010cause and cardiovascular mortality among US adults with arthritis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.70105","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T12:46:42Z","timestamp":1739278002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Life's Essential 8 and Risk of All\u2010Cause and Cardiovascular Mortality in <scp>US<\/scp> Adults With Arthritis: A Retrospective Cohort Study Utilizing <scp>NHANES<\/scp> Database"],"prefix":"10.1111","volume":"28","author":[{"given":"Feiyu","family":"Yao","sequence":"first","affiliation":[{"name":"Pediatric Hospital The First Affiliated Hospital of Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiafeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianhua","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Diabetes Research and Care  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po\u2010Cheng","family":"Shih","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, Rheumatology, Department of Internal Medicine Changhua Christian Hospital  Changhua Taiwan"},{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6691-7423","authenticated-orcid":false,"given":"Tuo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7040a2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6620a2"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6519a2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756\u2010185X.15447"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39692"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756\u2010185X.15367"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2022.2089911"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2006.10.001"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001078"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000533257"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.062457"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030564"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.01.200"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201059421\u20109"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2023.01.009"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2196\/45521"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwad040"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2023.01.021"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010023\u201002824\u20108"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102018\u2010213585"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42613"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102016\u2010209775"},{"issue":"19","key":"e_1_2_11_24_1","first-page":"614","article-title":"Arthritis as a Potential Barrier to Physical Activity Among Adults With Obesity\u2014United States, 2007 and 2009","volume":"60","author":"Centers for Disease Control and Prevention (CDC)","year":"2011","journal-title":"MMWR. 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