{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:36:22Z","timestamp":1768818982191,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Circadian rhythms have been shown to play a significant role in the etiology and progression of immune\u2010related morbidities, including cancer and autoimmune diseases. As an autoimmune disorder, psoriatic arthritis (PsA) has been underexplored in the context of circadian rhythms. This study aimed to explore the relationship between circadian rhythm and PsA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a Summary\u2010data\u2013based Mendelian randomization (SMR) analysis, obtaining summary data on gene methylation, expression, and protein abundance levels of circadian clock\u2010related genes (CRGs) from European ancestry individuals, with a total of 1749 genes selected from the GeneCards database using \u201cbiological clock\u201d as the search term. The discovery cohort was obtained from the GWAS catalog database, and the replication cohort was obtained from the FinnGen database. Candidate genes related to circadian rhythm and PsA were identified through research, and their pharmacological potential and molecular docking were further validated as drug targets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After integrating multi\u2010omics data, we identified 11 methylation sites in three genes (<jats:italic>HLA\u2010DQB1<\/jats:italic>, <jats:italic>ITPR3<\/jats:italic>, and <jats:italic>GABBR1<\/jats:italic>) of CRGs that were causally related to PsA, and the effects produced were not consistent. The three gene expressions of CRGs (<jats:italic>IL4<\/jats:italic>, <jats:italic>HLA\u2010DQB1<\/jats:italic>, and <jats:italic>OPI\u2010AIS5<\/jats:italic>) were related to PsA. At the protein level, we identified three proteins (GCKR, STAT3, and CSNK2B) of CRGs related to PsA. The top 20 drug candidates underwent drug prediction screening, resulting in the identification of 12 compounds that demonstrated effective outcomes with three (HLA\u2010DQB1, STAT3, and IL\u20104) specific therapeutic targets through molecular docking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests altered expression of circadian clock genes and proteins, including <jats:italic>HLA\u2010DQB1<\/jats:italic>, <jats:italic>ITPR3<\/jats:italic>, <jats:italic>GABBR1<\/jats:italic>, <jats:italic>IL4<\/jats:italic>, <jats:italic>OIP5\u2010AS1<\/jats:italic>, GCKR, CSNK2B, and STAT3, as factors contributing to the increased risk of PsA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.70158","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T06:12:02Z","timestamp":1741759922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploration of Circadian Clock\u2010Related Genes in the Pathogenesis of Psoriatic Arthritis to Identify Potential Therapeutic Targets From Multi\u2010Omics Insight: A Mendelian Randomization Study"],"prefix":"10.1111","volume":"28","author":[{"given":"Aimei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wuda","family":"Huoshen","sequence":"additional","affiliation":[{"name":"School of Stomatology Southwest Medical University  Luzhou Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Stomatology Southwest Medical University  Luzhou Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Affiliated Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5961-4167","authenticated-orcid":false,"given":"Zhen","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology The Affiliated Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X231174989"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201194"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-016-1111-9"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.285"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.31"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2019_243"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2016.04.007"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2019.1678629"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15555.1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a040501"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3538"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35871-w"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8935-6-4"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00978-w"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06592-6"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05473-8"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00954-4"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2021.0005"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.320374"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12855"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.102848"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2017.1385622"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2709266"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02078-6"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2019.102132"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14341"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep13953"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113000"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2017.1279054"},{"issue":"3","key":"e_1_2_12_32_1","first-page":"311","article-title":"Pustular Psoriasis Appearing Induced by Dupilumab Therapy in a Patient With Atopic Dermatitis","volume":"21","author":"Jia X.","year":"2022","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111366"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2023.2189136"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087523"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.09.003"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-219796"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0923-1811(94)00376-P"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12086"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.06.057"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-317411"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780381112"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-023-02001-9"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.70158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T12:36:20Z","timestamp":1751546180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.70158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/1756-185X.70158"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.70158","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70158"}}