{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:38:56Z","timestamp":1789133936705,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2023C03032"],"award-info":[{"award-number":["2023C03032"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2021KY765"],"award-info":[{"award-number":["2021KY765"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore the clinical characteristics and identify risk factors for early bone destruction in children with enthesitis\u2010related arthritis (ERA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical characteristics were retrospectively analyzed in 85 newly diagnosed cases with ERA at our hospital from January 2019 to December 2021. Logistic regression analyses were performed to identify risk factors for early bone destruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this cohort of 85 ERA patients, early bone destruction was identified in 24.7% (21\/85) of cases (ERA\u2010BD group), predominantly affecting the sacroiliac joints (66.7%), knee (14.3%), hip (14.3%), and interphalangeal joints (4.8%). The ERA\u2010BD group exhibited significantly higher rates of polyarticular involvement (\u2265\u20095 joints) compared to the ERA\u2010nBD group (76.2% vs. 12.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with a notably higher incidence of knee joint involvement (66.7% vs. 40.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and sacroiliitis (85.7% vs. 50.0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Additionally, the ERA\u2010BD group had a longer disease duration (8.0 vs. 3.5\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u20090.009) and elevated C\u2010reactive protein levels (median: 12.3 vs. 4.4\u2009mg\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.04). However, no significant differences were observed in ESR or IL\u20106 levels between the two groups. Multivariate analysis confirmed that polyarticular involvement (OR\u2009=\u200921.39, 95% CI 5.12\u201389.30) and longer disease duration (OR\u2009=\u20094.06, 95% CI 1.33\u201312.39) were independent predictors of early bone destruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study identifies polyarticular involvement (\u2265\u20095 joints) and longer disease duration as key independent predictors of early bone destruction in ERA, highlighting the need for a shift from joint\u2010specific to systemic risk stratification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.70176","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T10:59:03Z","timestamp":1742209143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Features and Risk Factors for Early Bone Destruction in Enthesitis\u2010Related Arthritis: A Cohort Study"],"prefix":"10.1111","volume":"28","author":[{"given":"Jianqiang","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Rheumatology Immunology and Allergy Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9407-6763","authenticated-orcid":false,"given":"Xiaolong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Immunology and Allergy Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minfei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pediatric The First Affiliated Hospital of Ningbo University  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Immunology and Allergy Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Immunology and Allergy Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Immunology and Allergy Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4930-9493","authenticated-orcid":false,"given":"Meiping","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Immunology and Allergy Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00332-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23853"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-023-01447-6"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199911)42:11<2319::AID-ANR9>3.0.CO;2-G"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-024-09486-5"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0805-0"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-017-0644-x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30173-8"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-024-00896-z"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22181"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead032"},{"key":"e_1_2_11_13_1","first-page":"390","article-title":"International League of Associations for Rheumatology Classification of Juvenile Idiopathic Arthritis: Second Revision, Edmonton, 2001","volume":"31","author":"Petty R. 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