{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:41:49Z","timestamp":1788522109270,"version":"build-2803163510"},"reference-count":73,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with diverse clinical manifestations and unpredictable progression, posing significant challenges to accurate diagnosis and effective treatment. Traditional biomarkers and treatments often fail to address the disease's molecular and clinical heterogeneity. Recent advancements in CRISPR gene\u2010editing technology and multiomics approaches offer transformative opportunities for personalized SLE care by unraveling its underlying molecular complexity and enabling precise therapeutic interventions. CRISPR technology allows targeted editing of SLE\u2010associated genetic mutations, addressing disease drivers directly, while multiomics\u2014including genomics, transcriptomics, and proteomics\u2014provides insights into dysregulated immune networks, identifying biomarkers and therapeutic targets. Integrating these approaches can refine patient stratification and enhance the precision of treatments. Artificial intelligence (AI) complements these technologies by synthesizing high\u2010dimensional data, enabling personalized treatment plans, predicting disease trajectories, and optimizing therapeutic strategies. However, the integration of CRISPR and multiomics in clinical settings raises challenges, including technical limitations, ethical concerns, and economic barriers. Emerging clinical trials and case studies demonstrate the potential of these innovations to personalize care and improve outcomes. Nonetheless, the transition from experimental research to routine clinical application requires robust regulatory frameworks and strategies to address these challenges. This review aims to explore the potential of CRISPR and multiomics technologies to revolutionize SLE diagnosis and therapy, emphasizing their integration with AI to advance personalized care. By addressing existing barriers, the review envisions a future where precision medicine transforms SLE management, paving the way for individualized, patient\u2010centered autoimmune therapy.<\/jats:p>","DOI":"10.1111\/1756-185x.70189","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:02:09Z","timestamp":1745456529000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Precision Reimagined:\n                    <scp>CRISPR<\/scp>\n                    and Multiomics Transform Systemic Lupus Erythematosus Diagnosis and Therapy"],"prefix":"10.1111","volume":"28","author":[{"given":"Zhuo","family":"Chen","sequence":"first","affiliation":[{"name":"The Second Clinical Medical College Zhejiang Chinese Medical University  Hangzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaheh","family":"Pilehvar","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences  Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences  Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0747-2321","authenticated-orcid":false,"given":"Younes","family":"Pilehvar","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences  Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-020-00123-w"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1257085"},{"issue":"2","key":"e_1_2_13_4_1","first-page":"A50","article-title":"PO. 2.48 Incomplete Systemic Lupus Erythematosus: Clinical and Immunological Manifestations","volume":"9","author":"Panafidina T.","year":"2022","journal-title":"Archives of Disease in Childhood"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/mr-2023-0032"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.11.001"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgeed.2023.1114996"},{"issue":"7","key":"e_1_2_13_8_1","first-page":"1496","article-title":"Navigating Challenges and Opportunities in Multi\u2010Omics Integration for Personalized Healthcare","volume":"12","author":"Mohr A. 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