{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T13:19:42Z","timestamp":1765372782423,"version":"3.46.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Intro<\/jats:title>\n                    <jats:p>In this prospective interventional study, we aimed to assess the efficacy and safety of the hepatitis A vaccine in patients with autoinflammatory diseases undergoing canakinumab and tocilizumab treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 24 patients with autoinflammatory diseases on canakinumab and tocilizumab treatments and 39 healthy children who were seronegative for hepatitis A were included in the study. All participants were vaccinated with 2 doses of inactivated hepatitis A vaccine at 6\u2010month intervals. One month after the last vaccination, venous blood samples were collected from each participant, and the anti\u2010HAV IgM and IgG titers were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The patient group consisted of 19 patients with systemic juvenile idiopathic arthritis (sJIA) and 5 patients with cryopyrin\u2010associated periodic fever. The mean age of the patient group and the healthy controls were 14.1\u2009\u00b1\u20093.7 and 12.4\u2009\u00b1\u20093.2\u2009years, respectively. All patients with cryopyrin\u2010associated periodic fever and 52.6% (10\/19) of the patients with sJIA were on canakinumab. The remaining 9 patients (47.3%) with sJIA were using tocilizumab. Among sJIA patients, 15 were also on methotrexate, and 14 were on prednisolone. All of the participants were negative for hepatitis A serology. After two doses of hepatitis A vaccine, all the patients with autoinflammatory diseases (24\/24) and 84.6% (33\/39) of the healthy controls were detected as positive for anti\u2010HAV IgG (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). The mean anti\u2010HAV Ig G titers of the patient group and the control group one month after the last dose of vaccination were 5.25\u2009\u00b1\u20091.49\u2009IU\/L and 10.5\u2009\u00b1\u20097.02\u2009IU\/L, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Neither disease flares nor adverse effects related to vaccination were observed within the study period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hepatitis A vaccine is effective and safe in children with autoinflammatory diseases on biologic therapy. Long\u2010term follow\u2010up data, including larger patient cohorts, are needed to draw a solid conclusion about the safety of hepatitis A vaccine in patients receiving canakinumab and tocilizumab therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70196","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T07:41:13Z","timestamp":1743752473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Efficacy and Safety of Hepatitis A Vaccine in Children and Young Adults With an Autoinflammatory Diseases on Canakinumab and Tocilizumab Treatments: A Prospective Observational Controlled Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8459-2872","authenticated-orcid":false,"given":"Kenan","family":"Barut","sequence":"first","affiliation":[{"name":"Department of Pediatric Rheumatology \u0130stanbul University\u2010Cerrahpa\u015fa Cerrahpa\u015fa  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7834-4909","authenticated-orcid":false,"given":"Mehmet","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology \u0130stanbul University\u2010Cerrahpa\u015fa Cerrahpa\u015fa  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6mer Faruk","family":"Be\u015fer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology, and Nutrition \u0130stanbul University\u2010Cerrahpa\u015fa Cerrahpa\u015fa  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6963-9668","authenticated-orcid":false,"given":"Fatih","family":"Haslak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology \u0130stanbul University\u2010Cerrahpa\u015fa Cerrahpa\u015fa  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0137-0460","authenticated-orcid":false,"given":"Aybuke","family":"Gunalp","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology \u0130stanbul University\u2010Cerrahpa\u015fa Cerrahpa\u015fa  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-5308","authenticated-orcid":false,"given":"Elif K\u0131l\u0131\u00e7","family":"Konte","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology \u0130stanbul University\u2010Cerrahpa\u015fa Cerrahpa\u015fa  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7554-3320","authenticated-orcid":false,"given":"Esma","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology \u0130stanbul University\u2010Cerrahpa\u015fa Cerrahpa\u015fa  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1282-8273","authenticated-orcid":false,"given":"\u00dcmit","family":"G\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology \u0130stanbul University\u2010Cerrahpa\u015fa Cerrahpa\u015fa  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-4055","authenticated-orcid":false,"given":"Nergis","family":"Akay","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology \u0130stanbul University\u2010Cerrahpa\u015fa Cerrahpa\u015fa  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2400-6955","authenticated-orcid":false,"given":"Amra","family":"Adrovic","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology \u0130stanbul University\u2010Cerrahpa\u015fa Cerrahpa\u015fa  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5365-3457","authenticated-orcid":false,"given":"Sezgin","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology \u0130stanbul University\u2010Cerrahpa\u015fa Cerrahpa\u015fa  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6998-5421","authenticated-orcid":false,"given":"Pelin Y\u00fcksel","family":"Mayda","sequence":"additional","affiliation":[{"name":"Kocaeli Health and Technology University, Faculty of Pharmacy  Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bekir","family":"Kocazeybek","sequence":"additional","affiliation":[{"name":"\u0130stanbul University\u2010Cerrahpa\u015fa Cerrahpa\u015fa Department of Medical Microbiology  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-7720","authenticated-orcid":false,"given":"\u00d6zg\u00fcr","family":"Kasap\u00e7opur","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology \u0130stanbul University\u2010Cerrahpa\u015fa Cerrahpa\u015fa  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"issue":"5","key":"e_1_2_9_2_1","first-page":"236","article-title":"Autoinflammatory Diseases in Childhood","volume":"37","author":"Y\u0131ld\u0131z M.","year":"2020","journal-title":"Balkan Medical Journal"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-021-00629-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000529917"},{"issue":"8","key":"e_1_2_9_5_1","first-page":"1567","article-title":"IL\u20101 Inhibition in Familial Mediterranean Fever: Clinical Outcomes and Expectations","volume":"40","author":"Kharouf F.","year":"2022","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/1984-0462\/2024\/42\/2022084"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2295"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-014-0432-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes175"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.956136"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11010151"},{"issue":"1","key":"e_1_2_9_12_1","first-page":"164","article-title":"Vaccination Coverage in Children With Rheumatic Diseases","volume":"38","author":"Bizjak M.","year":"2020","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-019-00270-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedhc.2006.12.011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.1920871"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v4.i3.68"},{"issue":"2","key":"e_1_2_9_17_1","first-page":"390","article-title":"International League of Associations for Rheumatology Classification of Juvenile Idiopathic Arthritis: Second Revision, Edmonton, 2001","volume":"31","author":"Petty R. E.","year":"2004","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215048"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-021-00518-0"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac123"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106293"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546\u20100096\u201013\u2010S1\u2010P1"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.10.035"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex185"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969\u2010018\u20100235\u2010z"},{"issue":"7","key":"e_1_2_9_26_1","first-page":"260","article-title":"Effect of Etanercept and Anakinra on Inflammatory Attacks in the Hyper\u2010IgD Syndrome: Introducing a Vaccination Provocation Model","volume":"63","author":"Bodar E. J.","year":"2005","journal-title":"Netherlands Journal of Medicine"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew239"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2023.101858"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30580"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102021\u2010221876"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00175-10"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41004"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.1149"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-017-0190-0"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2020.01.037"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.70196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T11:28:30Z","timestamp":1765366110000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.70196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/1756-185X.70196"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.70196","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"type":"print","value":"1756-1841"},{"type":"electronic","value":"1756-185X"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70196"}}