{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T05:01:31Z","timestamp":1772341291740,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Medications used for tuberculosis (TB) treatment are thought to increase uric acid levels and influence the occurrence of gout. The objective of this study was to evaluate the risk of gout in patients with TB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the South Korean National Health Claims database for incident cases of TB. After identifying patients diagnosed with gout within 6\u2009months of TB diagnosis, the risk compared to the general population was estimated by calculating the standardized incidence ratios (SIRs). A nested case\u2013control analysis among patients with TB was performed by matching subjects diagnosed with and without gout in a 1:5 ratio to identify the risk factors for gout.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 3848 patients with gout, the proportions of males, patients aged \u2265\u200970\u2009years, and those with a diagnosis within the first 2\u2009months were 70.2%, 33.0%, and 52.8%, respectively. The incidence of gout in patients with TB was significantly higher than in the general population (overall SIR: 1.42, sex\u2010adjusted SIR: 1.32, age\u2010adjusted SIR: 1.04). Conditional logistic regression analysis indicated that hypertension (odd ratio [OR] 1.43, 95% confidence interval (CI) 1.31\u20131.58), heart failure (OR 1.19, 95% CI 1.01\u20131.39), chronic kidney disease (OR 2.47, 95% CI 1.99\u20133.06), and use of pyrazinamide (OR 1.02, 95% CI 1.02\u20131.02) and ethambutol (OR 1.00, 95% CI 1.00\u20131.01) were associated with gout.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The increased risk of gout in patients with TB and the association between comorbidities and TB medications underscore the need for higher clinical awareness in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.70197","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T14:04:23Z","timestamp":1742825063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk of Gout Among Patients With Tuberculosis: A Nationwide Cohort Study in South Korea"],"prefix":"10.1111","volume":"28","author":[{"given":"Chi Young","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang Woo","family":"Ha","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Yongin Severance Hospital, Yonsei University College of Medicine  Yongin Gyeonggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inkyung","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Biomedical Systems Informatics Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minkyung","family":"Han","sequence":"additional","affiliation":[{"name":"Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9002-9880","authenticated-orcid":false,"given":"Sung Soo","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Yongin Severance Hospital, Yonsei University College of Medicine  Yongin Gyeonggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010019\u20100115\u2010y"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00569-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11010166"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.04.008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0441-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00372-9"},{"key":"e_1_2_10_8_1","unstructured":"Centers for Disease C Prevention \u201cTuberculosis. Global Health.\u201dCenters for Disease Control and Prevention Atlanta GA."},{"key":"e_1_2_10_9_1","unstructured":"World Health Organization \u201cTB Incidence. Global Tuberculosis.\u201dReport 2022. World Health Organization Geneva."},{"issue":"10","key":"e_1_2_10_10_1","first-page":"695","article-title":"Pyrazinamide\u2010Induced Hyperuricemia","volume":"39","author":"Pham A. Q.","year":"2014","journal-title":"Pharmacy and Therapeutics"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.5.718"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.550004"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5124\/jkma.2019.62.1.25"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-017-3768-4"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41404"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13697"},{"key":"e_1_2_10_17_1","volume-title":"Hyperuricemia","author":"George C.","year":"2023"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11020280"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087027"},{"issue":"12","key":"e_1_2_10_20_1","first-page":"831","article-title":"Diagnosis, Treatment, and Prevention of Gout","volume":"90","author":"Hainer B. L.","year":"2014","journal-title":"American Family Physician"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00851.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-015-0762-4"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2729"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2020.105092"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2020.0207"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.70197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T12:36:23Z","timestamp":1751546183000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.70197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/1756-185X.70197"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.70197","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70197"}}