{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:22:00Z","timestamp":1753878120906,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Studies have indicated a potential link between retinopathy and systemic sclerosis (SSc), but the precise nature of this association remains unclear. This systematic review and meta\u2010analysis aims to synthesize available evidence to evaluate the relationship between SSc and retinopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was conducted across four major databases and gray literature to collect all relevant studies. The quality of the selected articles was assessed for risk of bias using standardized tools.<\/jats:p><jats:p>A meta\u2010analysis was performed using standardized mean difference (Std. Mean Difference) to estimate the association between retinopathy and SSc. Additional analyses for heterogeneity, sensitivity, subgroups, and publication bias were also conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve studies (359 cases, 314 controls) were included in the systematic review. A meta\u2010analysis of eight studies found a nonsignificant and negligible association (pooled Std. Mean Difference\u2009=\u20090.08; 95% CI\u2009=\u2009\u22120.31 to 0.48; <jats:italic>p<\/jats:italic>\u2009=\u20090.67) between SSc and retinopathy, with no publication bias (<jats:italic>p<\/jats:italic>\u2009=\u20090.5362). Differences in Std. Mean Difference were observed in subgroup analyses but did not sufficiently explain the heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings suggest no strong association between retinopathy and SSc. While some subgroup analyses revealed potential variations, they did not fully clarify the observed heterogeneity. Further research with larger, well\u2010designed studies is necessary to determine whether retinopathy could serve as a biomarker for SSc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic Review Registration Number (<jats:styled-content style=\"fixed-case\">PROSPERO<\/jats:styled-content>)<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CRD42024529644<\/jats:styled-content> <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=529644\">https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=529644<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.70253","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T07:29:53Z","timestamp":1746689393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Retinopathy and Systemic Sclerosis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9305-9615","authenticated-orcid":false,"given":"Alireza","family":"Fatemi","sequence":"first","affiliation":[{"name":"Cardiovascular Surgery Research and Development Committee Iran University of Medical Sciences (IUMS)  Tehran Iran"},{"name":"Department of Surgery, Surgery Research Center, School of Medicine, Rasool\u2010E Akram Hospital Iran University of Medical Sciences (IUMS)  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aylin","family":"Taghipour","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Research and Development Committee Iran University of Medical Sciences (IUMS)  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Yazdooei","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Research and Development Committee Iran University of Medical Sciences (IUMS)  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdis","family":"Fatemi","sequence":"additional","affiliation":[{"name":"Iran University of Science and Technology  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akram","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Department of Medical Ethics, School of Medicine Iran University of Medical Sciences (IUMS)  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-5449","authenticated-orcid":false,"given":"Nafiseh","family":"Abdolahi","sequence":"additional","affiliation":[{"name":"Golestan Rheumatology Research Center, Biomedical Research Institute Golestan University of Medical Sciences  Gorgan Iran"},{"name":"Department of Medicine Western Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11092299"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-024-07123-y"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.31138\/mjr.34.1.61"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-021-08889-8"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.06.009"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.5301\/jsrd.5000249"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161\u20101149.1000235"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2020.102004"},{"issue":"5","key":"e_1_2_13_10_1","first-page":"627","article-title":"Ocular Manifestation in Systemic Sclerosis\u2014A Literature Review","volume":"14","author":"Paczwa K.","year":"2024","journal-title":"Lifestyles"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-019-01183-9"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13102738"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_264_19"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13072025"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12144817"},{"issue":"7","key":"e_1_2_13_16_1","article-title":"Prevalence and Determinants of Diabetic Retinopathy Among Type 2 Diabetic Patients in Saudi Arabia: A Systematic Review","volume":"15","author":"Aljehani E. 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