{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:28:25Z","timestamp":1789687705931,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The objective was to evaluate biologic disease\u2010modifying antirheumatic drugs (DMARDs) and their side effects that hindered the continuation of treatment in a patient population diagnosed with spondyloarthritis (SpA) with a glomerular filtration rate (GFR) \u2264\u200960\u2009mL\/min, and to compare these side effects between patients with chronic kidney disease (CKD) and those without.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter, observational cohort study utilized data from the TReasure database, which records SpA patients in a web\u2010based system across T\u00fcrkiye. A total of 6052 patients being included. SpA patients were categorized into two main groups: non\u2010CKD patients and CKD patients. The clinical characteristics, disease activity, treatment options, drug retention rates, reasons for drug discontinuation, and types of adverse effects were compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Biologics prescription pattern varied between CKD and non\u2010CKD patients. Etanercept was prescribed more frequently (53.1%) in CKD patients. Regarding the number of side effects and drug discontinuations in CKD patients, no statistically significant differences were found between the non\u2010CKD and CKD groups for any of the bDMARDs (adalimumab, etanercept, golimumab, infliximab, ustekinumab, secukinumab, and certolizumab). No statistically significant differences were observed in the duration of drug retention based on CKD status for bDMARDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study offers preliminary evidence supporting the effective and safe use of bDMARDs in patients with SpA and CKD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.70274","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T13:18:58Z","timestamp":1747142338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Real\u2010World Insights From T\u00fcrkiye: Biologic <scp>DMARDs<\/scp> Usage in Spondyloarthritis Patients With Chronic Kidney Disease"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9226-7532","authenticated-orcid":false,"given":"Dilara","family":"Bulut G\u00f6kten","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Tekirdag Namik Kemal University  Tekirdag T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1753-4936","authenticated-orcid":false,"given":"Mehmet Engin","family":"Tezcan","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Kartal Dr. L\u00fctfi K\u0131rdar City Hospital  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu","family":"Ya\u011f\u0131z","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Faculty of Medicine, Bursa Uludag University  Bursa T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulsamet","family":"Erden","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Gazi University  Ankara 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Nihan","family":"Co\u015fkun","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Faculty of Medicine, Bursa Uludag University  Bursa T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine Duygu","family":"Ers\u00f6zl\u00fc","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Adana City Research and Training Hospital  Adana T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhan","family":"K\u00fc\u00e7\u00fck\u015fahin","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Yildirim Beyazit University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fcleyman Serdar","family":"Koca","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Firat University  Elazig 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