{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:50:25Z","timestamp":1773312625983,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to evaluate and compare the efficacy and safety of tofacitinib versus methotrexate in the management of systemic lupus erythematosus (SLE) within a real\u2010world cohort, with a particular focus on mucocutaneous and musculoskeletal involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective analysis based on the Chinese SLE Treatment and Research Group (CSTAR) cohort. Patients with SLE presenting with active mucocutaneous or musculoskeletal involvement who initiated treatment with tofacitinib or methotrexate were included. The primary endpoint was the proportion of patients achieving resolution of mucocutaneous and musculoskeletal symptoms, as defined by the SLE Disease Activity Index 2000, at 3\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 109 patients were included in the study, with 44 assigned to the tofacitinib group and 65 to the methotrexate group. The tofacitinib group exhibited a numerically higher trend in resolution proportion for both mucocutaneous (3\u2009months: 88.0% vs. 69.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.162; 6\u2009months: 83.3% vs. 77.8%, <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.999) and musculoskeletal (100.0% vs. 84.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.555; 100.0% vs. 73.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.289) involvement compared with the methotrexate group. However, these differences did not reach statistical significance. Survival analysis revealed that tofacitinib was associated with a faster resolution of mucocutaneous (<jats:italic>p<\/jats:italic>\u2009=\u20090.043) involvement compared to methotrexate within a 6\u2010month follow\u2010up period. There was no significant difference in the incidence of adverse events between the two groups (2.3% vs. 3.1%, <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.999).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tofacitinib may demonstrate superior effectiveness over methotrexate in the resolution of mucocutaneous involvement in SLE patients, primarily by achieving remission more rapidly, while maintaining a comparable safety profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.70283","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T04:38:29Z","timestamp":1747975109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tofacitinib Versus Methotrexate in Treating Mucocutaneous and Musculoskeletal Lesions of Systemic Lupus Erythematosus: Real\u2010World Results From the <scp>CSTAR<\/scp> Cohort XXXII"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2250-4090","authenticated-orcid":false,"given":"Man","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC\u2010DID) Ministry of Science &amp; Technology  Beijing China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital  Beijing China"},{"name":"Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education  Beijing China"},{"name":"Department of Rheumatology People's Hospital of Zhengzhou  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4512-0700","authenticated-orcid":false,"given":"Leyao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC\u2010DID) Ministry of Science &amp; Technology  Beijing China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital  Beijing China"},{"name":"Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinwang","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The Second Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehong","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The Fifth People's Hospital of Datong  Datong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC\u2010DID) Ministry of Science &amp; Technology  Beijing China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital  Beijing China"},{"name":"Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1511-7952","authenticated-orcid":false,"given":"Xinping","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC\u2010DID) Ministry of Science &amp; Technology  Beijing China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital  Beijing China"},{"name":"Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunzhuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology People's Hospital of Zhengzhou  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengtao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC\u2010DID) Ministry of Science &amp; 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