{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:50:36Z","timestamp":1782125436043,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the clinical response to adalimumab (ADA) in patients with active radiographic axial spondyloarthritis (r\u2010axSpA) in Taiwan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this real\u2010world study, patients with r\u2010axSpA, starting ADA therapy, were enrolled and followed up every 12\u2009weeks for 48\u2009weeks. Outcome parameters were the proportion of patients with an improvement of 50% in Bath ankylosing spondylitis disease activity index (BASDAI50), inactive disease (ID, &lt;\u20091.3), and low disease activity (LDA, &lt;\u20092.1) per ankylosing spondylitis disease activity score\u2013C\u2010reactive protein (ASDAS\u2010CRP) and ASDAS\u2010erythrocyte sedimentation rate (ASDAS\u2010ESR), and change in peripheral and extra\u2010musculoskeletal manifestations. Determinants of BASDAI50 response to ADA were examined. Treatment\u2010emergent adverse events (TEAEs) were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 88 enrolled patients, 86 were analyzed, and 82 completed the study with all patients receiving 40\u2009mg ADA fortnightly. Patients achieving BASDAI50 increased from 79.1% to 80.5% from weeks 12 to 48. At week 48, ASDAS\u2010CRP and \u2010ESR, ID, and LDA were improved from baseline in 60.8%, 74.7%, 42.1%, and 68.4% of patients, respectively. A decrease in enthesitis, peripheral arthritis, dactylitis, and uveitis was noted. Younger age, presence of uveitis, and use of conventional synthetic disease\u2010modifying antirheumatic drugs were the determinants of treatment response. At least one TEAE was reported in 22.7%, serious AEs in 2.3% of patients, and no deaths. The most common TEAEs were upper respiratory tract infection (5.7%) and cough (3.4%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This real\u2010world, prospective study in Taiwan involving patients with active r\u2010axSpA shows that ADA treatment effectively reduced disease activity and improved physical function. No new safety concerns were noted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70285","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T01:24:07Z","timestamp":1748568247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Response to Adalimumab Therapy and Its Determinants in Patients With Radiographic Axial Spondyloarthritis: A Prospective Real\u2010World Study in Taiwan"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1291-8946","authenticated-orcid":false,"given":"Feng\u2010Cheng","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Immunology, and Allergy, Department of Internal Medicine Tri\u2010Service General Hospital, National Defense Medical Center  Taipei 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