{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:16:41Z","timestamp":1753877801755,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the clinical effectiveness of baricitinib and filgotinib in the treatment of rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 101 and 103 consecutive patients treated with baricitinib and filgotinib, respectively, between 2020 and 2023. Drug retention was analyzed using Kaplan\u2013Meier curves, with the log\u2010rank test for between\u2010group comparisons. Differences in Clinical Disease Activity Index (CDAI) score from baseline were assessed using paired <jats:italic>t<\/jats:italic>\u2010tests, and generalized estimating equations were used to compare the treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline characteristics were similar between the baricitinib and filgotinib groups. Drug retention rates due to ineffectiveness or adverse events did not differ significantly between the two groups. In the baricitinib group, the estimated mean CDAI score significantly decreased from 17.8 at baseline to 9.1 at 4\u2009weeks, 6.6 at 12\u2009weeks, and 6.3 at 24\u2009weeks (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for all comparisons). In the filgotinib group, the estimated mean CDAI score significantly decreased from 16.5 at baseline to 7.8 at 4\u2009weeks, 6.2 at 12\u2009weeks, and 6.1 at 24\u2009weeks (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for all comparisons). No significant differences were observed between the two groups in CDAI score at any time point evaluated, or in the proportion of patients who achieved CDAI remission (CDAI \u2264\u20092.8) at baseline (7% vs. 5%) and after 4 (23% vs. 21%), 12 (33% vs. 33%), and 24\u2009weeks (33% vs. 37%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Baricitinib and filgotinib demonstrated comparable drug retention rates and effectiveness in reducing disease activity among patients with RA over a 24\u2010week follow\u2010up period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.70288","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T04:41:23Z","timestamp":1747370483000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparable Clinical Effectiveness of Baricitinib and Filgotinib in Patients With Rheumatoid Arthritis"],"prefix":"10.1111","volume":"28","author":[{"given":"Hironobu","family":"Kosugiyama","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"},{"name":"Department of Rheumatology Shizuoka Kosei Hospital  Shizuoka Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4030-8793","authenticated-orcid":false,"given":"Shuji","family":"Asai","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenya","family":"Terabe","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Kobayakawa","sequence":"additional","affiliation":[{"name":"Kobayakawa Orthopedic and Rheumatologic Clinic  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Handa City Hospital  Handa Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Daido Hospital  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihisa","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology National Hospital Organization Nagoya Medical Center  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8936-4278","authenticated-orcid":false,"given":"Yasumori","family":"Sobue","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takefumi","family":"Kato","sequence":"additional","affiliation":[{"name":"Kato Orthopedic Clinic  Okazaki Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Fujibayashi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Konan Kosei Hospital  Konan Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Toyohashi Municipal Hospital  Toyohashi Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Nishiume","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Okazaki City Hospital  Okazaki Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihoko","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Shizuoka Kosei Hospital  Shizuoka Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2409-1619","authenticated-orcid":false,"given":"Yasuhide","family":"Kanayama","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Toyota Kosei Hospital  Toyota Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toki","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Anjo Kosei Hospital  Anjo Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Hanabayashi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Ichinomiya Municipal Hospital  Ichinomiya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Hekinan Municipal Hospital  Hekinan Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4895-5028","authenticated-orcid":false,"given":"Mochihito","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6499-2573","authenticated-orcid":false,"given":"Junya","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaya","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6937-3567","authenticated-orcid":false,"given":"Nobunori","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Aichi Medical University  Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Imagama","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Rheumatology Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard\u20102022\u2010223356"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41752"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/mr\/roac017"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/mr\/roab126"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/mr\/roac046"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40801\u2010024\u201000423\u20104"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010020\u201001349\u20101"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102020\u2010218398"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102020\u2010219012"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10165\u2010011\u20100518\u20104"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.201"},{"issue":"5","key":"e_1_2_11_14_1","first-page":"S100","article-title":"The Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI): A Review of Their Usefulness and Validity in Rheumatoid Arthritis","volume":"23","author":"Aletaha D.","year":"2005","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead543"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201078925\u20108"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.977265"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00393\u2010022\u201001165\u2010w"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0305621"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067\u2010023\u201006787\u20102"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmed\u20102016\u2010110401"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002808702101114"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead257"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102021\u2010221051"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102021\u2010221276"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn942"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190945"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109\u2010010\u20100697\u2010z"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34543"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067\u2010021\u201005815\u20103"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1608345"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102020\u2010219214"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0306548"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.23"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.2023\u20100145"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/35046102"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30074"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23372"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22453"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201009767\u20100"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.70288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T05:34:20Z","timestamp":1750656860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.70288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/1756-185X.70288"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.70288","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"type":"print","value":"1756-1841"},{"type":"electronic","value":"1756-185X"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70288"}}