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Patients with systemic autoimmune rheumatic diseases (SARDs) and hematological malignancies are particularly susceptible to developing SHG due to underlying diseases and the use of immunosuppressive medications, such as B\u2010cell\u2010targeted agents. Consequently, SHG significantly contributes to increased risks of severe infections and mortality in SARDs patients. Considering the lack of a unified strategy for managing SHG, the Taiwan College of Rheumatology (TCR) aimed to formulate consensus recommendations for the screening, diagnosis, and management of SHG. These recommendations were developed based on emerging evidence during a face\u2010to\u2010face meeting of the TCR committee (nine immunologists and rheumatologists), and utilizing the modified Delphi process. This meeting involved a comprehensive review of the current evidence, using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology. 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This consensus will be regularly updated as newer evidence emerges.<\/jats:p>","DOI":"10.1111\/1756-185x.70310","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T09:38:28Z","timestamp":1750066708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evidence\u2010 and Consensus\u2010Based Recommendations for the Screening, Diagnosis, and Management of Secondary Hypogammaglobulinemia in Patients With Systemic Autoimmune Rheumatic Diseases by the Taiwan College of Rheumatology Experts"],"prefix":"10.1111","volume":"28","author":[{"given":"Yen\u2010Po","family":"Tsao","sequence":"first","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Division of Holistic and Multidisciplinary Medicine, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of 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