{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:10:42Z","timestamp":1792098642991,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82330076"],"award-info":[{"award-number":["82330076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) are both prevalent inflammatory conditions within the population. Our objective was to explore the relationship between IBD and RA, while examining the role of inflammatory mediators in the observed association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used data from the UK Biobank, a population\u2010based prospective cohort study that recruited adults aged 37\u201373\u2009years from 22 centers in England, Scotland, and Wales between 2006 and 2010. We included patients diagnosed with IBD at baseline and excluded those with RA at baseline or missing follow\u2010up information. Cox regression proportional hazard models were employed to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) between patients with IBD (Ulcerative colitis and Crohn's disease) at baseline and the risk of RA. Additionally, we conducted mediation analysis to examine the roles of C\u2010reactive protein (CRP) and several composite inflammatory indices as potential mediators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After excluding participants with RA at baseline (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20096769), those lacking IBD subtype information (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009475), and those with missing covariate data (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009121\u2009195), a total of 373\u2009693 individuals were included in the analysis. Compared with individuals without IBD, those with IBD had a significantly higher risk of developing RA (hazard ratio 2.06, 95% confidence interval 1.69\u20132.51). This association remained robust after adjustment for multiple confounders and across all major subgroups. Notably, the risk of RA associated with IBD was even higher among individuals with a low polygenic risk score for RA. Mediation analysis showed that systemic inflammatory markers, such as CRP, explained only a modest proportion of the association between IBD and RA, with the highest mediation proportion observed being 9.56%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the UK Biobank cohort study, individuals with IBD demonstrated an increased risk of developing RA. Future research should aim to gain insight into these underlying mechanisms and explore ways to improve long\u2010term health outcomes in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70314","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:34:42Z","timestamp":1748997282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inflammatory Bowel Disease and Risk of Rheumatoid Arthritis: A\n                    <scp>UK<\/scp>\n                    Biobank Cohort Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0193-1098","authenticated-orcid":false,"given":"Kuangyu","family":"He","sequence":"first","affiliation":[{"name":"Department of Orthopedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"},{"name":"Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3163-2843","authenticated-orcid":false,"given":"Yi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"},{"name":"Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7790-3263","authenticated-orcid":false,"given":"Zhengqiang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"},{"name":"Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-426X","authenticated-orcid":false,"given":"Hao","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"},{"name":"Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1981-828X","authenticated-orcid":false,"given":"Yunhao","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"},{"name":"Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-2534","authenticated-orcid":false,"given":"Juehong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"},{"name":"Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1600-5693","authenticated-orcid":false,"given":"Yun","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"},{"name":"Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8673-9521","authenticated-orcid":false,"given":"Ziyang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"},{"name":"Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7854-5233","authenticated-orcid":false,"given":"Cunyi","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"},{"name":"Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665\u20109913(23)00211\u20104"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.10.020"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2103726"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010019\u201000964\u2010z"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i33.6137"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2007.01215.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i30.4819"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/Mib.0000000000000392"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91262-8"},{"key":"e_1_2_11_11_1","first-page":"699","article-title":"Reactive Arthropathy, Reiter's Syndrome and Enteric Arthropathy in Adults","volume":"2","author":"Amor B.","year":"1993","journal-title":"Oxford Textbook of Rheumatology"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281\u2010199507000\u201000004"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102014\u2010eular.5122"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200363"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20406"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2016.1211229"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)30173\u20108"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01525\u20108"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/es301948k"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.08.035"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.14309\/01.ajg.0000798612.41695.91"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy403"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022\u20103514.51.6.1173"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4067"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.3.387"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.03.040"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15076"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.049676"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.9.835"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.07.003"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.146357"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.076901"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010021\u201000585\u20103"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102021\u2010325209"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/16512235.2017.1322447"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102018\u2010eular.5899"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010019\u20100268\u20107"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39603"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m131"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx246"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.70314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.70314","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.70314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:11:33Z","timestamp":1782123093000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.70314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/1756-185X.70314"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.70314","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70314"}}