{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:19:43Z","timestamp":1792189183977,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to identify the risk factors for\n                      <jats:italic>Pneumocystis jirovecii<\/jats:italic>\n                      pneumonia (PCP) in patients with rheumatoid arthritis (RA) and to recommend appropriate disease\u2010modifying antirheumatic drug (DMARD) selection for those at high risk of developing PCP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective review of patients with RA who were treated with methotrexate or biologic and targeted synthetic DMARDs (b\/tsDMARDs). Patients with no chest computed tomography data or those receiving prophylactic sulfamethoxazole\u2013trimethoprim, atovaquone, or inhaled pentamidine were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 554 patients who met the inclusion and exclusion criteria, 16 developed PCP. Multivariate logistic analysis revealed interstitial pneumonia as a significant risk factor for PCP (odds ratio: 4.53, 95% confidence interval: 1.51\u201313.12), whereas salazosulfapyridine (SASP) use was associated with a reduced risk (odds ratio: 0.11, 95% confidence interval: 0.00\u20130.81). A Kaplan\u2013Meier analysis comparing the cumulative incidence of PCP between propensity score\u2010matched SASP users and nonusers further demonstrated that SASP use reduced the risk of developing PCP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with RA complicated by interstitial pneumonia are at a higher risk of developing PCP. Although methotrexate and b\/tsDMARDs do not increase the risk of developing PCP, SASP may potentially reduce the risk. A prospective study is warranted to investigate the efficacy and safety of SASP in patients with RA at high risk for PCP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70318","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:07:23Z","timestamp":1749726443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk Factors for\n                    <i>Pneumocystis jirovecii<\/i>\n                    Pneumonia in Rheumatoid Arthritis: The Protective Potential of Salazosulfapyridine"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1399-2198","authenticated-orcid":false,"given":"Yuki","family":"Hara","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine NHO Osaka Toneyama Medical Center  Toyonaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Nii","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Osaka Toneyama Medical Center  Toyonaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4416-6083","authenticated-orcid":false,"given":"Takanori","family":"Matsuki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Osaka Toneyama Medical Center  Toyonaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Tsujino","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Osaka Toneyama Medical Center  Toyonaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Osaka Toneyama Medical Center  Toyonaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Miyama","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery NHO Osaka Toneyama Medical Center  Toyonaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Takahi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery NHO Osaka Toneyama Medical Center  Toyonaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9351-7855","authenticated-orcid":false,"given":"Hiroshi","family":"Kida","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Osaka Toneyama Medical Center  Toyonaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc070728"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/mr\/roac078"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4472"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1903.121151"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2015.1118196"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"29","article-title":"Pneumocystis jirovecii Pneumonia in Rheumatoid Arthritis Patients: Risks and Prophylaxis Recommendations","volume":"9","author":"Mori S.","year":"2015","journal-title":"Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu185"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.843760"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-010-0406-3"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.072967"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2023.07.012"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6730812"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.8205-21"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223335"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2009.131668"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.47.0702"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565130-00008"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/4.2.426"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80401-X"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/520433"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae499"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu094"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1921-z"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2020.1772271"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.70318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.70318","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.70318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:12:56Z","timestamp":1782123176000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.70318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/1756-185X.70318"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.70318","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70318"}}