{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:17:24Z","timestamp":1790605044638,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016275","name":"Seoul National University Bundang Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Analyzing longitudinal real\u2010world data with nonuniform study\u2010time intervals is challenging. This study aimed to identify subgroups in heterogeneous clinical courses of idiopathic inflammatory myopathies\u2010associated interstitial lung disease (IIM\u2010ILD) using a growth rate model and to assess their prognostic significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cohort study, 243 chest high\u2010resolution computed tomography (HRCT) scans from 80 patients with IIM\u2010ILD were analyzed using a computer\u2010aided quantification system to estimate quantitative lung fibrosis (QLF) scores. Longitudinal patterns were identified through a growth\u2010rate model, and a landmark survival analysis was performed using the last HRCT date as an anchor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Using the growth\u2010rate model, we identified five different patterns in the serial QLF scores: progressive (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919), improving (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920), convex (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910), others (mostly concave,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922), and stable (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099). When the group with the progressive pattern was divided into the rapid progression and slow progression by the median progression rate (\n                      <jats:bold>\n                        <jats:italic>g<\/jats:italic>\n                      <\/jats:bold>\n                      \u2009=\u20091.029%\/month), the rapid progressive group was significantly associated with mortality (Hazard ratio 15.926, 95% confidence interval 1.079\u2013548.324,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043), compared to the reference group. However, the intensity of immunosuppression or QLF scores at landmark time were not associated with mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combined volumetric measurement of lung fibrosis and application of growth\u2010rate model had the potential to identify subgroups in analyzing complex, dynamic real\u2010world data of IIMs\u2010ILD. This approach may help extrapolate the future course and provide useful information about prognosis in patients with ILD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70320","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T11:05:14Z","timestamp":1749467114000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Application of a Growth\u2010Rate Model to Enhance Subgroup Identification in Heterogeneous Clinical Courses of the Idiopathic Inflammatory Myopathy\u2010Associated Interstitial Lung Disease and Its Prognostic Implication"],"prefix":"10.1111","volume":"28","author":[{"given":"Jiahao","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Biostatistics Fielding School of Public Health, UCLA  Los Angeles California 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