{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:31:05Z","timestamp":1793370665878,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the strength of the association of systemic lupus erythematosus (SLE) with feto\u2010maternal outcomes compared to those without SLE (healthy controls) beyond 20\u2009weeks of gestation, and to determine the factors associated with a flare during pregnancy and postpartum among those with SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This matched\u2010observational study was conducted between 2011 and 2020 in a tertiary referral center in southeastern India, comparing feto\u2010maternal outcomes such as preterm birth, hypertensive disorders of pregnancy (HDP), small for gestational age (SGA), among pregnancies that crossed 20\u2009weeks, with and without SLE (ratio of 1:1). Rates of lupus flare among cases were studied. Conditional logistic regression assessed the association between SLE and fetal\u2010maternal outcomes matched for age, whereas factors associated with lupus flare were assessed by multivariate logistic regression, expressed as adjusted odds ratios (OR) with a 95% confidence interval (95% CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the study period, there were 144 cases of SLE, and 27 (18.8%) were diagnosed for the first time during pregnancy. Those with SLE had higher odds for HDP (OR: 5.10, 95% CI: 2.39\u201310.88), SGA (OR: 2.21, 95% CI: 1.24\u20133.91), preterm birth (&lt;\u200937\u2009weeks) (OR: 2.61, 95% CI: 1.36\u20135.02), and perinatal loss (OR: 13.92, 95% CI: 1.79\u2013108.45), than those without SLE (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009144). The most common neonatal lupus presentation was complete heart block. Among those with SLE, HDP (OR: 9.99, 95% CI: 2.42\u201341.26) and lupus nephritis (OR: 4.62, 95% CI: 1.21\u201317.63) increased the risk of perinatal loss. Flares occurred in 27 (18.8%) cases, with six having multiple flares, and hydroxychloroquine was associated with its reduction (OR: 0.15, 95% CI: 0.03\u20130.71).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pregnant women with SLE had a higher risk of adverse feto\u2010maternal outcomes than those without SLE, beyond 20\u2009weeks of gestation. Lupus nephritis and HDP increase the risk of perinatal loss, whereas hydroxychloroquine usage reduces lupus flare.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70328","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T09:43:20Z","timestamp":1750067000000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pregnancy Outcomes in Women With Systemic Lupus Erythematosus (\n                    <scp>SLE<\/scp>\n                    ): A Matched\u2010Observational Study From India"],"prefix":"10.1111","volume":"28","author":[{"given":"Prajwal","family":"Mohan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Jawaharlal Institute of Postgraduate Medical Education &amp; Research  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3643-3989","authenticated-orcid":false,"given":"Kavadichanda G.","family":"Chengappa","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Jawaharlal Institute of Postgraduate Medical Education &amp; Research  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotsna","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Jawaharlal Institute of Postgraduate Medical Education &amp; Research  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avantika","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Jawaharlal Institute of Postgraduate Medical Education &amp; Research  Puducherry India"},{"name":"Department of Obstetrics and Gynaecology All India Institute of Medical Sciences (AIIMS)  Bhopal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethou","family":"Adhisivam","sequence":"additional","affiliation":[{"name":"Department of Neonatology Jawaharlal Institute of Postgraduate Medical Education &amp; Research  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1518-6031","authenticated-orcid":false,"given":"Vir Singh","family":"Negi","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Jawaharlal Institute of Postgraduate Medical Education &amp; Research  Puducherry India"},{"name":"All India Institute of Medical Sciences (AIIMS)  Bilaspur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4881-0382","authenticated-orcid":false,"given":"Anish","family":"Keepanasseril","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Jawaharlal Institute of Postgraduate Medical Education &amp; Research  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19-0120"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2180-z"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.02.009"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019797"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.13-6-580"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00668-1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223035"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1183712"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00069"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.07.023"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2020-000400"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203320944503"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac530"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0190-1"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.37737\/ace.22005"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159364"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.8.577"},{"issue":"4","key":"e_1_2_11_20_1","first-page":"466","article-title":"Predictors of Adverse Pregnancy Outcome in a Cohort of Women With Systemic Lupus Erythematosus in Malaysia","volume":"76","author":"Ong S. 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