{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:21:38Z","timestamp":1788481298707,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC0615"],"award-info":[{"award-number":["2024NSFSC0615"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Endophilin A2 (EPA2) is a member of the Endophilin family. The relationship between EPA2 and SLE pathogenesis is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Plasma levels of EPA2 in SLE patients and healthy controls were detected by ELISA, and EPA2 mRNA levels of SLE patients were explored by qRT\u2010PCR. EPA2 siRNA adenovirus was further injected into pristane\u2010induced lupus mice, and the histological and serological changes were observed. In\u00a0vitro, EPA2 siRNA adenovirus was transfected to human umbilical vein endothelial cells (HUVECs) in the presence of growth differentiation factor 15 (GDF15), and the proliferation, migration, and tube\u2010forming ability of HUVECs were discussed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Plasma EPA2 levels were significantly higher in SLE patients than in healthy controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and EPA2 mRNA levels were significantly higher in SLE patients than in healthy controls as well (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030). Lupus mice exhibited splenomegaly, severe histologic damage, and high levels of autoantibodies (antinuclear antibody (ANA), anti\u2010double\u2010stranded DNA antibody (anti\u2010dsDNA), and immunoglobulin G (IgG)) (vs. the control group, all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). After injection of EPA2 siRNA adenoviruses, the lupus mice showed a lower proportion of CD11b\n                      <jats:sup>+<\/jats:sup>\n                      LY\u20106C\n                      <jats:sup>+<\/jats:sup>\n                      , F4\/80\n                      <jats:sup>+<\/jats:sup>\n                      , CD11c\n                      <jats:sup>+<\/jats:sup>\n                      , CD19\n                      <jats:sup>+<\/jats:sup>\n                      , CD8\n                      <jats:sup>+<\/jats:sup>\n                      , Th1\n                      <jats:sup>+<\/jats:sup>\n                      , Th2\n                      <jats:sup>+<\/jats:sup>\n                      , Th17\n                      <jats:sup>+<\/jats:sup>\n                      cells and reduced expression of pro\u2010inflammatory cytokines, and autoantibodies (vs. the adenoviral empty vector group, all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Addition of EPA2 siRNA adenovirus to HUVECs resulted in decreased GDF15 mRNA levels and reduced cell proliferation, migration and tube formation. However, in the presence of GDF15, EPA2\u2010mediated effects were reversed, and the proliferation, migration, and tube formation ability of HUVECs were enhanced.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EPA2 may regulate angiogenesis through GDF15, and then involve in SLE pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70343","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T07:19:37Z","timestamp":1751354377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Endophilin A2, a Potential Therapeutic Target for Lupus, Promotes Lupus Progression"],"prefix":"10.1111","volume":"28","author":[{"given":"Lu\u2010Qi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Evidence\u2010Based Medicine School of Public Health, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Yu","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology The Affiliated Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Yu","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Evidence\u2010Based Medicine School of Public Health, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3860-8383","authenticated-orcid":false,"given":"An\u2010Fang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology The Affiliated Hospital, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8276-1249","authenticated-orcid":false,"given":"Wang\u2010Dong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Evidence\u2010Based Medicine School of Public Health, Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2024.152556"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756\u2010185X.15278"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.974826"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13557"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756\u2010185X.15214"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201010106\u20102"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.3528"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2010.12.3717"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/371496"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2016.06.017"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.03.151"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277\u2010016\u20105092\u20100"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058\u2010017\u20100900\u2010z"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577\u2010017\u20100178\u20106"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201020586\u20102"},{"issue":"6","key":"e_1_2_11_17_1","first-page":"435","article-title":"Comparative Analysis of Sequence Alignment of SH3GL1 Gene as a Disease Candidate Gene of Adolescent Idiopathic Scoliosis","volume":"48","author":"Yang T.","year":"2010","journal-title":"Zhonghua Wai Ke Za Zhi"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264\u2010011\u20101419\u2010z"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201010359\u2010x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.926373"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201009210\u20104"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872\u2010021\u201002420\u20109"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2021.06.007"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012826"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011\u2010023\u201001760\u2010w"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113945"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.892169"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202051328"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1297506"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2017.0137"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.09.045"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.60110"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2022.2088731"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756\u20109966\u201031\u201085"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.70343","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.70343","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.70343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:12:59Z","timestamp":1782123179000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.70343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/1756-185X.70343"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.70343","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70343"}}