{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:10:20Z","timestamp":1791461420596,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>IgA vasculitis (IgAV) and Kawasaki disease (KD) are the most common forms of childhood vasculitis. Although various factors such as viral infections, genetic factors, and environmental factors are involved in the development of both diseases, their pathogenesis remains unclear. The interferon (IFN) signature, which reflects the activation of type I IFN signaling pathways, is a diagnostic and prognostic tool that contributes significantly to the pathogenesis and management of autoimmune diseases. In our study, we aimed to investigate the role of the IFN signature in patients with IgAV and KD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010two children with IgAV and four patients diagnosed with KD were included in the study. Serum levels of IL\u20101, IL\u20106, IL\u20108, IL\u201010, IL\u201017, IL\u201018, TNF\u2010\u03b1, TNF\u2010R1, TNF\u2010R2, and IFN\u2010gamma were analyzed in the serum samples of all participants, and the expression of IFN\u2010related genes (\n                      <jats:italic>STAT1, IFI27, IFI44, IFI44L, IFIT1<\/jats:italic>\n                      , and\n                      <jats:italic>RSAD2<\/jats:italic>\n                      ) was assessed in the patients and healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926) to calculate the IFN score by RT\u2010PCR method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant increase in the expression of three genes (\n                      <jats:italic>IFIT1, IFI44,<\/jats:italic>\n                      and\n                      <jats:italic>IFI27<\/jats:italic>\n                      ) and decreased expression of the other three genes (\n                      <jats:italic>RSAD2, STAT1<\/jats:italic>\n                      , and\n                      <jats:italic>IFI44L<\/jats:italic>\n                      ) was found in patients with IgAV and KD compared to the control group. Significantly higher IFN scores (IFN &gt;\u20093) were found in patients with gastrointestinal involvement, in patients who required corticosteroid therapy, and in patients who had to be hospitalized. No significant difference in IFN levels was found between patients with and without renal involvement. Significantly higher serum IL\u20101 levels were found in patients with gastrointestinal symptoms with IgAV. High IFN scores were found in three out of four patients diagnosed with KD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A dysregulated type 1 IFN signature was found in patients with IgAV and KD compared to the control group. A significantly increased risk of gastrointestinal involvement required corticosteroid therapy, and hospitalization was observed in patients diagnosed with IgAV who had high IFN levels. This underlines the idea that the IFN score could serve as a crucial prognostic indicator.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70349","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T08:41:05Z","timestamp":1751359265000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patients With\n                    <scp>IgA<\/scp>\n                    Vasculitis and Kawasaki Disease Show Dysregulated Interferon Signature"],"prefix":"10.1111","volume":"28","author":[{"given":"Sevki Erdem","family":"Varol","sequence":"first","affiliation":[{"name":"Department of Pediatrics Cerrahpasa School of Medicine, Istanbul University\u2010Cerrahpasa  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cisem","family":"Cinar","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Cerrahpasa School of Medicine, Istanbul University\u2010Cerrahpasa  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihan","family":"Burtecene","sequence":"additional","affiliation":[{"name":"Department of Pediatric Immunology and Allergy Cerrahpasa School of Medicine, Istanbul University\u2010Cerrahpasa  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sezgin","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Cerrahpasa School of Medicine, Istanbul University\u2010Cerrahpasa  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Cerrahpasa School of Medicine, Istanbul University\u2010Cerrahpasa  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenan","family":"Barut","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Cerrahpasa School of Medicine, Istanbul University\u2010Cerrahpasa  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haluk","family":"Cokugras","sequence":"additional","affiliation":[{"name":"Department of Pediatric Immunology and Allergy Cerrahpasa School of Medicine, Istanbul University\u2010Cerrahpasa  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinem","family":"Firtina","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Cerrahpasa School of Medicine, Istanbul University\u2010Cerrahpasa  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-7720","authenticated-orcid":false,"given":"Ozgur","family":"Kasapcopur","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Cerrahpasa School of Medicine, Istanbul University\u2010Cerrahpasa  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5821-3963","authenticated-orcid":false,"given":"Ayca","family":"Kiykim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Immunology and Allergy Cerrahpasa School of Medicine, Istanbul University\u2010Cerrahpasa  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000236"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32835d8e2a"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.771619"},{"key":"e_1_2_8_5_1","article-title":"A Review of IgA Vasculitis (Henoch\u2010Sch\u00f6nlein Purpura) Past, Present, and Future","volume":"30","author":"Parums D. V.","year":"2024","journal-title":"Medical Science Monitor"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2017.11.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5152\/TurkArchPediatr.2024.24181"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01445.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0667"},{"issue":"4","key":"e_1_2_8_10_1","doi-asserted-by":"crossref","DOI":"10.5152\/TurkPediatriArs.2015.2363","article-title":"Diagnostic Approach and Current Treatment Options in Childhood Vasculitis","volume":"50","author":"Barut K.","year":"2015","journal-title":"Turkish Archives of Pediatrics\/T\u00fcrk Pediatri Ar\u015fivi"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000002161"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000484"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-020-00941-4"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241813948"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32835c7e32"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2119\/2006-00085.Baechler"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.10.020"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000653"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcp.2020.0008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2017.0127"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.12.012"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20203-9"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100486"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu299"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-87760-4"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.10.023"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-004-1726-3"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009749709065719"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2013.850028"},{"issue":"1","key":"e_1_2_8_30_1","first-page":"114","volume":"28","author":"Torres O.","year":"2010","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930232000114535"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00502-X"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080405"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051105"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00422933"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.09.022"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2019.1687074"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2022.09.030"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000001683"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.70349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.70349","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.70349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:12:31Z","timestamp":1782123151000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.70349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/1756-185X.70349"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.70349","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70349"}}