{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:09:34Z","timestamp":1793912974476,"version":"4.8.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study investigates antimigratory, anti\u2010invasive, and anti\u2010inflammatory mechanisms of Bergenin in patients with rheumatoid arthritis (RA) by focusing on the pathways involved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In vitro, TNF\u2010\u03b1\u2010induced MH7A cells were used to assess Bergenin's effects on cell proliferation (CCK\u20108), migration (wound healing, Transwell assays), and apoptosis (flow cytometry). mRNA levels of IL\u20106 and MMPs were quantified by qRT\u2010PCR, and protein expression was analyzed using ELISA and western blot. The Wnt\/\u03b2\u2010catenin pathway was examined through immunofluorescence and western blotting with or without LiCl. An adjuvant\u2010induced arthritis (AIA) rat model was used to monitor clinical symptoms and analyze synovial tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Bergenin inhibited the proliferation, migration, and invasion of TNF\u2010\u03b1\u2010induced MH7A cells, while promoting apoptosis. It reduced IL\u20106 and MMPs expression, with these effects reversed by LiCl. In\u00a0vivo, Bergenin alleviated paw swelling, arthritis score, and synovial pathology in AIA rats, reducing pro\u2010inflammatory factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Bergenin exerts antimigratory, anti\u2010invasive, and anti\u2010inflammatory effects in rheumatoid arthritis by modulating the Wnt\/\u03b2\u2010catenin pathway, suggesting its potential as a therapeutic option for rheumatoid arthritis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70360","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T03:56:19Z","timestamp":1751860579000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antimigratory, Anti\u2010Invasive and Anti\u2010Inflammatory Effects of Bergenin in Rheumatoid Arthritis by Downregulating the Wnt\/\u03b2\u2010Catenin Pathway"],"prefix":"10.1111","volume":"28","author":[{"given":"Haoyu","family":"Yang","sequence":"first","affiliation":[{"name":"Suzhou Medical College of Soochow University  Suzhou China"},{"name":"Department of Orthopedics Wuxi Ninth People's Hospital Affiliated to Soochow University  Wuxi Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhou","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Wuxi Ninth People's Hospital Affiliated to Soochow University  Wuxi Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University  Suzhou China"},{"name":"Department of Orthopedics Wuxi Ninth People's Hospital Affiliated to Soochow University  Wuxi Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6282-7825","authenticated-orcid":false,"given":"Jingyi","family":"Mi","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University  Suzhou China"},{"name":"Department of Orthopedics Wuxi Ninth People's Hospital Affiliated to Soochow University  Wuxi Jiangsu 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