{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:50:56Z","timestamp":1782125456299,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reactive arthritis (ReA) is a lower\u2010limb predominant oligoarthritis that follows genitourinary or gastrointestinal infection with a 2\u20134\u2009week latency. Up to 40% can progress to chronicity. There is no approved disease\u2010modifying anti\u2010rheumatic drug for ReA yet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty consecutive patients of ReA, defined by Braun criteria, refractory to NSAIDs were included, with 25 in each group (Sulfasalazine group, tofacitinib group). Forty\u2010six patients completed the study. The primary endpoint was DAREA (Disease Activity Index for the Assessment of Reactive Arthritis) at week 12 between the two groups. Complete response (CR), partial response (PR) and no response (NR) were defined based on DAREA of \u2264\u20095, 6\u201310, and &gt;\u200910, respectively. Secondary endpoints were pain VAS, ESR, CRP, BASFI, MASES, and ASDAS\u2010CRP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 46 patients who completed the study, 70% were males, with HLA\u2010B27 positivity in 65%. Twenty\u2010one received sulfasalazine and 25, tofacitinib. The median DAREA at 12\u2009weeks [3.35 (IQR: 2.77\u20139.18) vs. 3.05 (IQR: 2.69, 8.45), respectively)] was comparable between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.545). The decline in CRP, ESR, and DAREA was quicker in the tofacitinib group (by week 4). Change from baseline to 12\u2009weeks in DAREA and the secondary endpoints was statistically significant within both groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). 25% of patients in the tofacitinib group and 18.2% in the sulfasalazine group had NR. There were no serious adverse events in either group by week 12.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sulfasalazine and tofacitinib showed comparable effectiveness and safety in NSAID\u2010refractory ReA at 12\u2009weeks, with tofacitinib exhibiting a more rapid onset of therapeutic response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70370","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T05:59:02Z","timestamp":1753163942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Short\u2010Term Effectiveness of Sulfasalazine and Tofacitinib in\n                    <scp>NSAID<\/scp>\n                    \u2010Refractory Reactive Arthritis: An Observational Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1278-6042","authenticated-orcid":false,"given":"Prakashini","family":"Mruthyunjaya","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Kalinga Institute of Medical Sciences, KIIT Deemed\u2010to\u2010be University  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8093-8303","authenticated-orcid":false,"given":"Debashis","family":"Maikap","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Kalinga Institute of Medical Sciences, KIIT Deemed\u2010to\u2010be University  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4631-311X","authenticated-orcid":false,"given":"Sakir","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Kalinga Institute of Medical Sciences, KIIT Deemed\u2010to\u2010be University  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7921-4199","authenticated-orcid":false,"given":"Ramnath","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Kalinga Institute of Medical Sciences, KIIT Deemed\u2010to\u2010be University  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2545-9032","authenticated-orcid":false,"given":"Prasanta","family":"Padhan","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Kalinga Institute of Medical Sciences, KIIT Deemed\u2010to\u2010be University  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0973369820080205"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.005"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/mrcr\/rxab029"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/mrcr\/rxab014"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.191307"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20191927"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24899"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1399249"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780391211"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199911)42:11<2325::AID-ANR10>3.0.CO;2-C"},{"key":"e_1_2_14_12_1","unstructured":"\u201cMachine Learning Models Identify Gut Microbiota That Predict Chronicity in Reactive Arthritis \u201dACR Meeting Abstracts https:\/\/acrabstracts.org\/abstract\/machine\u2010learning\u2010models\u2010identify\u2010gut\u2010microbiota\u2010that\u2010predict\u2010chronicity\u2010in\u2010reactive\u2010arthritis\/."},{"issue":"9","key":"e_1_2_14_13_1","first-page":"2185","article-title":"On the Difficulties of Establishing a Consensus on the Definition of and Diagnostic Investigations for Reactive Arthritis. Results and Discussion of a Questionnaire Prepared for the 4th International Workshop on Reactive Arthritis, Berlin, Germany, July 3\u20136, 1999","volume":"27","author":"Braun J.","year":"2000","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223296"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.101501"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-219601"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1615977"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.8.955"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780391210"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.56.1.32"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009748809105304"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00726-8"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003668"},{"issue":"11","key":"e_1_2_14_24_1","first-page":"2285","article-title":"Th1\/Th17 Cytokine Profiles in Patients With Reactive Arthritis\/Undifferentiated Spondyloarthropathy","volume":"34","author":"Singh R.","year":"2007","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2017.03.016"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1646-5"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185x.70370","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185x.70370","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185x.70370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:12:56Z","timestamp":1782123176000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185x.70370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/1756-185x.70370"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.70370","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70370"}}