{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:56:49Z","timestamp":1783792609397,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001745","name":"Asia Pacific League of Associations for Rheumatology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001745","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Under the auspices of the Asia\u2010Pacific League of Associations for Rheumatology (APLAR), we aimed to develop broad, evidence\u2010 and consensus\u2010based guidelines to aid health professionals managing patients with psoriatic arthritis (PsA) in the region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A working group of 35 members comprising rheumatologists, dermatologists, and patient research partners from 18 <jats:styled-content style=\"fixed-case\">APLAR<\/jats:styled-content> countries was convened. The working group conducted systematic literature reviews to derive the quality of evidence via <jats:styled-content style=\"fixed-case\">GRADE<\/jats:styled-content> methods in supporting the efficacy and safety of classes of therapeutic agents for the management of active <jats:styled-content style=\"fixed-case\">PsA<\/jats:styled-content>, its comorbidities, and screening for specific infection concerns in the region. Recommendation statements on the principles of management and the best use of therapeutic drugs were developed. Consensus within the working group was achieved. An external voting panel, five from each of the 18 <jats:styled-content style=\"fixed-case\">APLAR<\/jats:styled-content> countries, was convened to confirm further agreement on the recommendation statements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The main literature review included 178 articles from clinical trials for PsA. Additional articles on the evidence for managing comorbidities, uveitis, inflammatory bowel disease, and screening for chronic hepatitis B and latent tuberculosis were reviewed. The working group discussed and reached consensus on eight management principles and 16 recommendation statements for managing PsA. Endorsement from an external voting panel (<jats:italic>n<\/jats:italic>\u2009=\u200990, response rate 80%) was achieved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These first recommendations for the management of PsA patients in the APLAR regions were developed based on the best available evidence and region\u2010specific considerations through discussion among rheumatologists, dermatologists, and patients, with strong agreement from an external expert panel.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.70372","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T05:03:22Z","timestamp":1753765402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The APLAR Recommendations for the Management of Psoriatic Arthritis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8492-6342","authenticated-orcid":false,"given":"Ying\u2010Ying","family":"Leung","sequence":"first","affiliation":[{"name":"Department of Rheumatology Singapore General Hospital  Singapore Singapore"},{"name":"Duke\u2010NUS Medical School  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bird","sequence":"additional","affiliation":[{"name":"University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Haroon","sequence":"additional","affiliation":[{"name":"Fatima Memorial Hospital, and FMH College of Medicine and Dentistry  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsumasa","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6749-7598","authenticated-orcid":false,"given":"Kichul","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Rheumatology College of Medicine, Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish Jacob","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Christian Medical College  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heizel","family":"Reyes","sequence":"additional","affiliation":[{"name":"University of the Philippines  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Chau","sequence":"additional","affiliation":[{"name":"Patient Research Partner  Hong Kong, SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Neuen","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4253-9229","authenticated-orcid":false,"given":"Praveena","family":"Chiowchanwisawakit","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9140-5860","authenticated-orcid":false,"given":"Asal Adnan","family":"Ridha","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Internal Medicine University of Baghdad, College of Medicine  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanhui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Allergy and Immunology Tan Tock Seng Hospital  Singapore Singapore"},{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Taylor","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Hutt Hospital, Health New Zealand (Te Whatu Ora)  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8139-7764","authenticated-orcid":false,"given":"Fariz","family":"Yahya","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-9390","authenticated-orcid":false,"given":"Ho","family":"So","sequence":"additional","affiliation":[{"name":"Department of Medicine &amp; 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