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The development process adhered to standard methodologies, including PICO (population, intervention, comparator, and outcomes) question deconstruction, systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) for evidence and recommendation evaluation, Delphi voting, and expert consensus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The guideline presents 26 evidence\u2010based recommendations addressing seven clinical questions for patients with hyperuricemia and gout in the context of comorbidities. Key recommendations include the maintenance of strict serum urate targets, particularly for patients with CKD stage \u2265\u20093, chronic gouty arthritis, and OA, in order to prevent disease progression. In patients with CVD or diabetes, intra\u2010articular triamcinolone is preferred over systemic glucocorticoids. Prioritized anti\u2010inflammatory treatments for patients with CKD, gastrointestinal diseases, and OA are recommended. The guideline also introduces emerging therapies, such as interleukin\u20101 inhibitors and selective urate transport inhibitors, as potential treatment options for refractory cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The update offers a comprehensive, patient\u2010centered approach to managing gout, particularly in individuals with associated comorbidities. Multidisciplinary collaboration and emerging new treatments and evidence ensure the optimization of the recommendations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.70402","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T05:45:49Z","timestamp":1756100749000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["2024 Update of Chinese Guidelines for Management of Hyperuricemia and Gout Part <scp>II:<\/scp> Recommendations for Patients With Common Comorbidities"],"prefix":"10.1111","volume":"28","author":[{"given":"Changgui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology Xiang'an Hospital of Xiamen University  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingshu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Xiang'an Hospital of Xiamen University  Xiamen Fujian 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