{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:06:48Z","timestamp":1782490008705,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Gout, a chronic inflammatory condition, is intricately linked to lifestyle factors such as diet and alcohol consumption. Alcohol significantly influences gout development and flares through mechanisms including hyperuricemia, oxidative stress, and purine metabolism. The impact of alcohol varies by type and quantity, with beer and spirits posing a higher risk due to their purine and ethanol content, while moderate wine consumption may confer potential anti\u2010inflammatory benefits. Recent advances underscore the multifactorial nature of gout, revealing how host genetics and epigenetic modifications modulate alcohol's effects. Variants in genes regulating urate transport (SLC2A9, ABCG2) and alcohol metabolism (ADH1B, ALDH2) influence individual susceptibility, highlighting the need for personalized management strategies. This narrative review synthesizes evidence from genetics, lifestyle, and public health perspectives, emphasizing the importance of moderation, pharmacogenomics, and tailored interventions in improving gout outcomes.<\/jats:p>","DOI":"10.1111\/1756-185x.70421","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T06:51:28Z","timestamp":1758351088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the Relationship Between Alcohol Consumption and Gout: A Narrative Review"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1542-0249","authenticated-orcid":false,"given":"Mar\u00eda Cristina","family":"Mart\u00ednez\u2010\u00c1vila","sequence":"first","affiliation":[{"name":"Internal Medicine Department Fundaci\u00f3n Santa Fe de Bogota  Bogot\u00e1 Colombia"},{"name":"School of Medicine Universidad El Bosque  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6111-902X","authenticated-orcid":false,"given":"Paul Alejandro","family":"Mendez\u2010Patarroyo","sequence":"additional","affiliation":[{"name":"Rheumatology Division University Hospital Fundaci\u00f3n Santa Fe de Bogot\u00e1  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alieth Luc\u00eda","family":"Acosta Cardozo","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Fundaci\u00f3n Santa Fe de Bogota  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2734-7210","authenticated-orcid":false,"given":"Gerardo","family":"Quintana\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Rheumatology Division University Hospital Fundaci\u00f3n Santa Fe de Bogot\u00e1  Bogot\u00e1 Colombia"},{"name":"Rheumatology Division Universidad Nacional de Colombia  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0684-9542","authenticated-orcid":false,"given":"Wilson","family":"Bautista\u2010Molano","sequence":"additional","affiliation":[{"name":"School of Medicine Universidad El Bosque  Bogot\u00e1 Colombia"},{"name":"Rheumatology Division University Hospital Fundaci\u00f3n Santa Fe de Bogot\u00e1  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000028"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14173525"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1906"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010024\u201001921\u20105"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16000-5"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3527579"},{"issue":"1","key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.35946\/arcr.v35.1.02","article-title":"Alcohol Metabolism and Epigenetics Changes","volume":"35","author":"Zakhari S.","year":"2013","journal-title":"Alcohol Research: Current Reviews"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes169"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13101519"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0115-y"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1911928"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201215"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.3398"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211873"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2319-y"},{"key":"e_1_2_11_17_1","article-title":"Ethanol\u2010Induced Oxidative Stress and Mitochondrial Dysfunction","volume":"36","author":"He L.","year":"2020","journal-title":"Redox Biology"},{"key":"e_1_2_11_18_1","first-page":"2028","article-title":"ROS\u2010Induced NLRP3 Inflammasome Activation: Mechanisms and Therapeutic Potential","volume":"9","author":"Zhao J.","year":"2018","journal-title":"Frontiers in Immunology"},{"issue":"2","key":"e_1_2_11_19_1","first-page":"243","article-title":"Alcohol, Oxidative Stress, and Inflammation: Focus on the Gut\u2013Liver\u2013Brain Axis","volume":"38","author":"Molina P. 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