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Spontaneous resolution of gout is defined as the self\u2010resolution of acute gouty arthritis observed in some patients within 7\u201310\u2009days without pharmacological intervention, with no residual sequelae. The mechanistic basis underlying this spontaneous resolution remains incompletely understood, involving a spectrum of biological entities including immune cells, RNA, neutrophil extracellular traps, inflammatory mediators, and pattern recognition receptors. This review synthesizes current research progress on the spontaneous resolution of gout, with the objective of delineating directions for future investigations.<\/jats:p>","DOI":"10.1111\/1756-185x.70427","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:50:17Z","timestamp":1760003417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Decoding the Spontaneous Resolution Nature of Gout: Molecular Crosstalk Between Immune Cells, Neutrophil Extracellular Traps, Non\u2010Coding\n                    <scp>RNAs<\/scp>\n                    , and Inflammatory Factors"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7668-1520","authenticated-orcid":false,"given":"Jing","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology The Affiliated Hospital of Inner Mongolia Medical University  Hohhot 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