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Over the past few decades, various susceptibility factors for RA have been revealed, and numerous therapeutic drugs have been developed, including analgesics, glucocorticoids, non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs), disease\u2010modifying antirheumatic drugs (DMARDs), and biological agents (bDMARDs). Despite the availability of multiple treatment options, the therapeutic outcomes for some patients remain suboptimal due to the complex pathogenesis of RA. As a key pathological mechanism, programmed cell death (PCD) in RA has received extensive attention. Dysregulation of PCD in RA impacts the progression of the disease. This article systematically reviews the roles of various cell death modalities, including apoptosis, necroptosis, ferroptosis, pyroptosis, and autophagy in the pathophysiology of RA, aiming to provide a theoretical basis and direction for the discovery of new therapeutic targets and drug development.<\/jats:p>","DOI":"10.1111\/1756-185x.70445","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:30:22Z","timestamp":1761219022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dysregulation of Different Modes of Programmed Cell Death in Rheumatoid Arthritis Fibroblast\u2010Like Synoviocyte"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2536-4611","authenticated-orcid":false,"given":"Xiaorong","family":"Zhi","sequence":"first","affiliation":[{"name":"School of Clinical and Basic Medical Sciences Shandong First Medical University &amp; 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