{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T06:07:46Z","timestamp":1771135666887,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03CA273608"],"award-info":[{"award-number":["R03CA273608"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001445","name":"Alex's Lemonade Stand Foundation for Childhood Cancer","doi-asserted-by":"publisher","award":["17\u201001882"],"award-info":[{"award-number":["17\u201001882"]}],"id":[{"id":"10.13039\/100001445","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112\u20102314\u2010B\u2010006\u2010068\u2010MY3"],"award-info":[{"award-number":["NSTC 112\u20102314\u2010B\u2010006\u2010068\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113\u20102629\u2010H\u2010006\u2010002\u2010SS2"],"award-info":[{"award-number":["113\u20102629\u2010H\u2010006\u2010002\u2010SS2"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Autoimmune diseases (ADs) are characterized by a loss of immune tolerance to self\u2010antigens. Maternal ADs are associated with pregnancy complications and are related to various diseases among their offspring. Existing studies have reported that maternal ADs increase the risk of certain types of malignancies in children. We aimed to investigate the association between maternal ADs and childhood cancer in Taiwan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We established a population\u2010based cohort study using the Taiwan Maternal and Child Health Database, which links parents to their children, and connected it to the Taiwan Cancer Registry to identify cases of childhood cancer. Cox proportional hazard modeling was used to examine the association between maternal ADs and childhood cancer. Further analysis of exposure to overall maternal ADs and incident individual childhood cancer types was performed and stratified by child sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 2004 to 2015, there were a total of\u20092\u2009385\u2009071 live births in Taiwan; 97\u2009138 were exposed to maternal ADs. Certain types of organ\u2010specific maternal ADs, including gastrointestinal and skin ADs, were weakly associated with overall childhood cancers. Compared to their counterparts, offspring exposed to maternal ADs were at risk of developing CNS tumors and neuroblastoma. Exposed female offspring had a higher risk of medulloblastoma and hepatoblastoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study implicates the association between maternal ADs and childhood cancer. Future research is required to elucidate the pathogenesis of the increased risk of childhood cancer among exposed offspring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.70457","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T06:01:02Z","timestamp":1765432862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Autoimmune Disease and the Risk of Childhood Cancer Among the Offspring: A Population\u2010Based Cohort Study in Taiwan"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2072-7277","authenticated-orcid":false,"given":"Ya\u2010Chun","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Hui","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8713-8413","authenticated-orcid":false,"given":"Julia E.","family":"Heck","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health University of California  Los Angeles California USA"},{"name":"College of Health and Public Service University of North Texas  Denton Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng\u2010Yu","family":"Weng","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7813-0823","authenticated-orcid":false,"given":"Pei\u2010Chen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"UVSQ, Inserm, Gustave Roussy, CESP Universit\u00e9 Paris\u2010Saclay  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.03.012"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203319877258"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203319877258"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12050741"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5009"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(17)30186\u20109"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(19)30339\u20100"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039986"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr516"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201020\u20101704"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S147188"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15821"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010022\u201001961\u2010w"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13728"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcped.2024.100145"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102794"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32905"},{"key":"e_1_2_12_19_1","volume-title":"National Health Insurance Annual Report 2014\u20102015","author":"National Health Insurance Administration, Ministry of Health and Welfare, Taiwan, R.O.C","year":"2014"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.6288\/TJPH201635104053"},{"issue":"4","key":"e_1_2_12_21_1","first-page":"297","article-title":"Validation of the Taiwan Birth Registry Using Obstetric Records","volume":"103","author":"Lin C. 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